About: Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show that AC membrane translocation and pore-forming (hemolytic) activity of CyaA depends on a predicted transmembrane amphipathic α-helix, localized between residues 565 and 591 of the pore-forming domain and comprising pair of glutamate residues, Glu570 and Glu581. Moreover, we show for the first time that different amino acid substitutions of the glutamate residue at position 516 can increase the hemolytic activity of CyaA by two different molecular mechanisms We show that AC membrane translocation and pore-forming (hemolytic) activity of CyaA depends on a predicted transmembrane amphipathic α-helix, localized between residues 565 and 591 of the pore-forming domain and comprising pair of glutamate residues, Glu570 and Glu581. Moreover, we show for the first time that different amino acid substitutions of the glutamate residue at position 516 can increase the hemolytic activity of CyaA by two different molecular mechanisms (en) Ukázali jsme, že translokace AC domény a kanálotvorná (hemolytická) aktivita CyaA závisí na predikovaném transmebránovém amfipatickém α-helixu, který je lokalizován mezi aminokyselinovými zbytky 565 a 591 v hydrofóbní doméně a zahrnuje dva glutamátové zbytky, Glu570 a Glu581. Dále jsme poprvé ukázali, že různé aminokyselinové záměny glutamátového zbytku v pozici 516 mohou zvyšovat hemolytickou aktivitu CyaA dvěmi různými molekulárními mechanizmy (cs)
Title	Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin (en) Segmenty klíčové pro translokaci a kanálotvornou aktivitu adenylát-cyklázového toxinu z Bordetella pertussis (cs)
skos:prefLabel	Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin (en) Segmenty klíčové pro translokaci a kanálotvornou aktivitu adenylát-cyklázového toxinu z Bordetella pertussis (cs)
skos:notation	RIV/61388971:_____/07:00085770!RIV08-AV0-61388971
http://linked.open.../vavai/riv/strany	12419;12429
http://linked.open...avai/riv/aktivita	P R Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(IAA5020406), R, Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Osička, Radim Basler, Marek Šebo, Peter Mašín, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mikrobiologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	449197
http://linked.open...ai/riv/idVysledku	RIV/61388971:_____/07:00085770
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bordetella; adenylate cyclase toxin; ac membrane translocation (en)
http://linked.open.../riv/klicoveSlovo	bordetella adenylate cyclase toxin ac membrane translocation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C85C6B2B673F]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology Mechanisms of membrane interaction and cytotoxic activity of adenylate cyclase
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	282
http://linked.open...iv/tvurceVysledku	Osička, Radim Šebo, Peter Basler, Marek Mašín, Jiří Fišer, R. Benz, R. Knapp, O. Maier, E.
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology
issn	0021-9258
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin Segments Crucial for Membrane Translocation and Pore-forming Activity of Bordetella Adenylate Cyclase Toxin

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