About: DENDRIMERS IN BIOMEDICAL APPLICATIONS

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=OC10053
Description	Dendrimers are recently of the high interest of the biomedical scientific comunity for theirunique properties. Structural features of these monodisperse macromolecules (lot of surface groups which could be properly modified, existence of internal cavities) make them suitable for many biomedical applications, especially for drug delivery. They can bind drugs to the surface or within their cavities. The main objective of our project is to study dendrimers and dendrimer-nucleic acid complexes by means of the computer multiscale modeling. Apart of it an experimental studies will be also performed with the aim to exploit the dendrimers in development of biosensors for biomedical diagnostics. (en) Ve spolupráci se zahraničními pracovišti podpořit základní výzkum v oblasti použití dendrimerů pro pro léčbu rakoviny, Alzheimerovy nemoci a.j. a v oblasti využití dendrimerů pro nanobioanalytická zařízení.
Title	DENDRIMERS IN BIOMEDICAL APPLICATIONS (en) Dendrimery v biomedicínských aplikacích
skos:notation	OC10053
http://linked.open...avai/cep/aktivita	COST
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/OC10053/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/OC10053/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2013-06-28 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	92928281
http://linked.open...ai/cep/hlavniObor	CE - Biochemie
http://linked.open...hodnoceniProjektu	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	dendrimer; oligonucleotide; dendriplex; biosensor; metalo-nanocomposite (en)
http://linked.open...ep/partnetrHlavni	Přírodovědecká fakulta
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open.../pocetVysledkuRIV	19 (xsd:int)
http://linked.open...enychVysledkuVRIV	19 (xsd:int)
http://linked.open...lneniVMinulemRoce	2012-02-27 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/1081%2F2011-320
http://linked.open...iciPoslednihoRoku	2012
http://linked.open...atUdajeProjZameru	2013
http://linked.open.../vavai/cep/soutez	SMSM2010OC5
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2012-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	CD - Makromolekulární chemie CF - Fyzikální chemie a teoretická chemie
http://linked.open...ep/zahajeniReseni	2010-05-01 (xsd:date)
http://linked.open...jektu+dodavatelem	We have obtained and original knowledge about the interaction of four degradable carbosilane dendrimes with single stranded oligonucleotides GEM 91 and ANTI TAR valuable for development of novel drug-delivery vehicules for gene therapy (anti-sense therapy). We have documented self-assembled processes of maltose-modified PPI dendrimers with oligonucleotides (dendriplexes). (en) Kombinací řady biofyzikálních metod a počítačového modelování jsme získali originální poznatky o interakci čtyř různých typů degradovatelných karbosilanových dendrimerů s jednořetězcovými oligonukleotidy GEM 91a ANTI TAR a to v kontextu vývoje nosičů pro cílený transport oligonukleotidů. Zdokumentovali jsme samoskladné procesy maltózou modifikovaných PPI dendrimerů s oligonukleotidy. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	dendrimer biosensor dendriplex oligonucleotide
is http://linked.open...vavai/riv/projekt of	PAMAM Dendrimers for siRNA Delivery: Computat Intrinsically disordered enamel matrix protein ameloblastin forms ribbon-like supramolecular structures via an N-terminal segment encoded by exon 5 A Molecular Simulation Study of Adsorption of Nitrogen and Methane in Titanium Silicate (ETS-4) An Introduction to Coarse-Graining Approaches: Linking Atomistic and Mesoscales Self-Assembly of Lamellar- and Cylinder-Forming Diblock Copolymers in Planar Slits: Insight from Dissipative Particle Dynamics Simulations A Molecular Simulation Approach to the Prediction of the Morphology of Self-Assembled Nanoparticles in Diblock Copolymers Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems Molecular Simulation of Aqueous Electrolyte Solubility. 2. Osmotic Ensemble Monte Carlo Methodology for Free Energy and Solubility Calculations and Application to NaCl Preparation and characterization of new hybrid nanostructured thin films for biosensors design Carbosilane Dendrimers are a Non-Viral Delivery System for Antisense Oligonucleotides: Characterization of Dendriplexes Carbosilane dendrimer nanotechnology outlines of the broad HIV blocker profile Synthesis of Large Dendrimers with the Dimensions of Small Viruses Influence of surface groups on poly(propylene imine) dendrimers antiprion activity Highly Organized Self-Assembled Dendriplexes Based on Poly(propylene imine) Glycodendrimer and Anti-HIV Oligodeoxynucleotides Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease Adsorption Behavior of Model Proteins on Surfaces Holder for microfluid chip of polydimethyl siloxane polymer Molecular Simulation of Aqueous Electrolyte Solubility. 3. Alkali-Halide Salts and Their Mixtures in Water and in Hydrochloric Acid Synthesis, structure and molecular modelling of anionic carbosilane dendrimers
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10053/2010/orjk%3A13440 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10053/2011/orjk%3A13440 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10053/2012/orjk%3A13440 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/OC10053/2013/orjk%3A13440

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