About: Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Granular non-fibrillar aggregates (GNAs) are identified as possible toxic species in Alzheimer's disease. GNAs form on the surface of negatively charged biological membranes and as a consequence of an acidic environment, off the polymerization pathway at neutral pH. A beta (1-40) GNAs disturb the bilayer structure of model membranes and seem to be more toxic to cells with negatively charged membranes (consequence of chronic pre-apoptosis). GNAs may be relevant in physiological situations associated to Alzheimer's disease: a local acidic pH at the cell surface (consequence of lipid oxidation or other cell insults) and acidification as a consequence of vascular events causing hypoxia. Together with previous descriptions of granular aggregates with poly-glutamine peptides related to Huntington's disease and the SH3 domain of PI3, GNAs related to Alzheimer's disease are a further example of a possible common aggregation and toxicity mechanism in conformational diseases. GNAs may represent a new pharmacological target in Alzheimer's disease. Granular non-fibrillar aggregates (GNAs) are identified as possible toxic species in Alzheimer's disease. GNAs form on the surface of negatively charged biological membranes and as a consequence of an acidic environment, off the polymerization pathway at neutral pH. A beta (1-40) GNAs disturb the bilayer structure of model membranes and seem to be more toxic to cells with negatively charged membranes (consequence of chronic pre-apoptosis). GNAs may be relevant in physiological situations associated to Alzheimer's disease: a local acidic pH at the cell surface (consequence of lipid oxidation or other cell insults) and acidification as a consequence of vascular events causing hypoxia. Together with previous descriptions of granular aggregates with poly-glutamine peptides related to Huntington's disease and the SH3 domain of PI3, GNAs related to Alzheimer's disease are a further example of a possible common aggregation and toxicity mechanism in conformational diseases. GNAs may represent a new pharmacological target in Alzheimer's disease. (en)
Title	Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease (en)
skos:prefLabel	Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease (en)
skos:notation	RIV/44555601:13440/12:43884111!RIV13-MSM-13440___
http://linked.open...avai/predkladatel	Přírodovědecká fakulta
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(KAN200520702), P(OC10053)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Malý, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Jana Evangelisty Purkyně v Ústí nad Labem / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	138392
http://linked.open...ai/riv/idVysledku	RIV/44555601:13440/12:43884111
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipid oxidation; phosphatidylserine; Electrophoresis; pH; non-fibrillar; membranes; amyloid; Alzheimer's (en)
http://linked.open.../riv/klicoveSlovo	lipid oxidation pH membranes Alzheimer's non-fibrillar phosphatidylserine amyloid Electrophoresis
http://linked.open...odStatuVydavatele	AE - Stát Spojené arabské emiráty
http://linked.open...ontrolniKodProRIV	[7A758A0D278D]
http://linked.open...i/riv/nazevZdroje	Current Alzheimer Research
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	DENDRIMERS IN BIOMEDICAL APPLICATIONS Nanoimmunosensors for detection of cytokines
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Malý, Jan Benseny-Cases, N. Cladera, J. Klementieva, O.
http://linked.open...ain/vavai/riv/wos	000309510400009
issn	1567-2050
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.2174/156720512803251129
http://localhost/t...ganizacniJednotka	13440
is http://linked.open...avai/riv/vysledek of	Granular Non-Fibrillar Aggregates and Toxicity in Alzheimer's Disease

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