About: Eribulin Mesylate

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Attributes	Values
rdf:type	Class
rdfs:label	Eribulin Mesylate
rdfs:subClassOf	Vinca-Domain Binding Agent nodeID://b668251 nodeID://b668252 nodeID://b668253 nodeID://b668254
Has_Free_Acid_Or_Base_Form	ERIBULIN
Has_Target	Tubulin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Eribulin Mesylate
NSC_Code	707389
UMLS_CUI	C2608038
CAS_Registry	253128-41-5
Accepted_Therapeutic_Use_For	Breast Cancer
In_Clinical_Trial_For	Non-Small Cell Lung Cancer and Advanced Solid Tumors.
FDA_UNII_Code	AV9U0660CW
Contributing_Source	FDA
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitubulin agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID	257773
PDQ_Closed_Trial_Search_ID	257773
Chemical_Formula	C40H59NO11.CH4O3S
Legacy_Concept_Name	E7389
FULL_SYN	2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-oneSNNCI E7389PTNCI-GLOSSCDR0000285632 E7389CNNCI Eribulin MesylatePTNCI ERIBULIN MESYLATEPTFDAAV9U0660CW HalavenBRNCI ER-086526CNNCI Halichondrin B AnalogSYNCI
DEFINITION	The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.NCI
code	C26644
sameAs	ERIBULIN MESYLATE
is Has_Salt_Form of	ERIBULIN
is sameAs of	ERIBULIN MESYLATE ERIBULIN MESYLATE

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