About: Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture.

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About: Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Goto Sponge Distinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Increased cytosolic calcium ([Ca2+]i) and nitric oxide (NO) are associated with apoptosis that is a main feature of many liver diseases and is characterized by biochemical and morphological features. Our data suggest that the extent of the [Ca2+]i increase and the modulation of NO production due to thapsigargin treatment contribute to hepatocyte apoptotic and/or necrotic events. Increased cytosolic calcium ([Ca2+]i) and nitric oxide (NO) are associated with apoptosis that is a main feature of many liver diseases and is characterized by biochemical and morphological features. Our data suggest that the extent of the [Ca2+]i increase and the modulation of NO production due to thapsigargin treatment contribute to hepatocyte apoptotic and/or necrotic events. (en) Zvýšená koncentrace intracelulárního vápníku a oxidu dusnatého je spojená s apoptózou, která charakterizuje mnoho jaterních onemocnění, doprovázených biochemickými a biochemickými změnami. Zjistili jsme, že zvýšení intracelulárního vápníku a modulaci produkce oxidu dusnatého je možné považovat za faktory, které přispívají k apoptóze a/nebo nekróze hepatocytů. (cs)
Title	Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Thapsigargin, selektivní inhibitor Ca2+-ATPas sarko-endoplasmatického retikula, moduluje produkci oxidu dusnatého a smrt kultivovaných jaterních hepatocytů potkanů. (cs) Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. (en)
skos:prefLabel	Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Thapsigargin, selektivní inhibitor Ca2+-ATPas sarko-endoplasmatického retikula, moduluje produkci oxidu dusnatého a smrt kultivovaných jaterních hepatocytů potkanů. (cs) Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. (en)
skos:notation	RIV/68378041:_____/07:00098472!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany	337;354
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/05/2425), P(GA305/07/0061), Z(AV0Z50390512), Z(MSM0021620807)
http://linked.open...iv/cisloPeriodika	-
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Zídek, Zdeněk Kmoníčková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	454960
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/07:00098472
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apoptosis; Intracellular free calcium; Necrosis (en)
http://linked.open.../riv/klicoveSlovo	Necrosis Apoptosis Intracellular free calcium
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[670B403CFB50]
http://linked.open...i/riv/nazevZdroje	Cell Biology and Toxicology
http://linked.open...in/vavai/riv/obor	FE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunopharmacological potential of endoplasmic Ca(2+)-ATPase (SERCA) inhibitors Apoptotic liver injury: possible pharmacological intervention and potential implications in hepatoprotection
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	23
http://linked.open...iv/tvurceVysledku	Martínek, J. Zídek, Zdeněk Farghali, H. Kmoníčková, Eva Kutinová-Canová, N.
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie
issn	0742-2091
number of pages	18 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture.

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