About: Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Beta-arrestins were originally identified as negative regulators of G protein-coupled receptor signalling, which can also serve as intracellular scaffolds and signalling intermediates. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signalling. Current findings implicates beta-arrestin as a determinant of WNT signalling specificity, a mediator of WNT/FZD desensitization and a regulator of signalling compartmentation. Beta-arrestins were originally identified as negative regulators of G protein-coupled receptor signalling, which can also serve as intracellular scaffolds and signalling intermediates. Here, we summarize the importance of beta-arrestin function for WNT/Frizzled (FZD) signalling. Current findings implicates beta-arrestin as a determinant of WNT signalling specificity, a mediator of WNT/FZD desensitization and a regulator of signalling compartmentation. (en)
Title	Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (en)
skos:prefLabel	Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? (en)
skos:notation	RIV/68081707:_____/10:00351340!RIV11-GA0-68081707
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/09/0498), P(GC204/09/J030), P(KJB501630801), Z(AV0Z50040507), Z(AV0Z50040702), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bryja, Vítězslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	248433
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/10:00351340
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	beta-arrestin; Wnt signaling; dishevelled (en)
http://linked.open.../riv/klicoveSlovo	Wnt signaling beta-arrestin dishevelled
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5323CA1A66B9]
http://linked.open...i/riv/nazevZdroje	British Journal of Pharmacology
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Posttranslational modification of Dishevelled The role of beta-arrestin in achieving Wnt-signaling specificity Dynamics of proteins interacting with Dishevelled and their importance for Wnt signalling
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	159
http://linked.open...iv/tvurceVysledku	Bryja, Vítězslav Schambony, A. Schulte, G.
http://linked.open...ain/vavai/riv/wos	000275402000007
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	0007-1188
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways? Beta-arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

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