About: DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei

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About: DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DEAD-box RNA helicase, a putative subunit of the mitochondrial ribosome of Trypanosoma brucei, has been down-regulated in the procyclic and bloodstream stage by RNA interference. Although ablation of the transcript leads to a week growth phenotype in the procyclic cells, the protein does not seem to be essential for mitochondrial translation under standard cultivation conditions, as shown by an assay that allows visualization of the de novo synthesized proteins. Furthermore, we show that synthesis of cytochrome c oxidase subunit I and cytochrome b does not occur in the mitochondrion of the bloodstream stage. DEAD-box RNA helicase, a putative subunit of the mitochondrial ribosome of Trypanosoma brucei, has been down-regulated in the procyclic and bloodstream stage by RNA interference. Although ablation of the transcript leads to a week growth phenotype in the procyclic cells, the protein does not seem to be essential for mitochondrial translation under standard cultivation conditions, as shown by an assay that allows visualization of the de novo synthesized proteins. Furthermore, we show that synthesis of cytochrome c oxidase subunit I and cytochrome b does not occur in the mitochondrion of the bloodstream stage. (en)
Title	DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei (en)
skos:prefLabel	DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei (en)
skos:notation	RIV/60077344:_____/11:00359433!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/09/1667), P(LC07032), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Richterová, Lenka Vávrová, Zuzana Lukeš, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	193012
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00359433
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trypanosoma; Mitochondrial translation; RNA helicase; Cytochrome c oxidase; Mitochondrion (en)
http://linked.open.../riv/klicoveSlovo	Mitochondrion Trypanosoma Cytochrome c oxidase Mitochondrial translation RNA helicase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9B60B530EABF]
http://linked.open...i/riv/nazevZdroje	Experimental Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	127
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Richterová, Lenka Vávrová, Zuzana
http://linked.open...ain/vavai/riv/wos	000286486800046
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0014-4894
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.exppara.2010.06.036
is http://linked.open...avai/riv/vysledek of	DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei

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