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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Esomeprazole
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Esomeprazole
UMLS_CUI
  • C0937846
CAS_Registry
  • 119141-88-7
FDA_UNII_Code
  • N3PA6559FT
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that blocks acid from being made in the stomach. It is used to treat acid reflux disease and to prevent certain types of gastrointestinal ulcers. Esomeprazole is being studied in the prevention of esophageal cancer and in the treatment of other conditions, including side effects of chemotherapy. It is a type of anti-ulcer agent.NCI-GLOSS
Chemical_Formula
  • C17H19N3O3S
Legacy_Concept_Name
  • Esomeprazole
CHEBI_ID
  • CHEBI:50275
FULL_SYN
  • ESOMEPRAZOLEPTFDAN3PA6559FT
  • EsomeprazolePTNCI
  • esomeprazolePTNCI-GLOSSCDR0000518308
DEFINITION
  • The S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.NCI
code
  • C65538
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
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