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AttributesValues
rdf:type
rdfs:label
  • Esomeprazole Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Esomeprazole Sodium
UMLS_CUI
  • C1337241
CAS_Registry
  • 161796-78-7
FDA_UNII_Code
  • L2C9GWQ43H
Contributing_Source
  • FDA
Chemical_Formula
  • C17H18N3O3S.Na
Legacy_Concept_Name
  • Esomeprazole_Sodium
FULL_SYN
  • Esomeprazole SodiumPTNCI
  • ESOMEPRAZOLE SODIUMPTFDAL2C9GWQ43H
  • 1H-Benzimidazole, 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2- pyridinyl)methyl]sulfinyl]-, Sodium Salt (1:1)SNNCI
DEFINITION
  • The sodium salt of the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.NCI
code
  • C65539
sameAs
is Has_Salt_Form of
is sameAs of
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