About: Esomeprazole Magnesium     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Esomeprazole Magnesium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Esomeprazole Magnesium
UMLS_CUI
  • C0937622
CAS_Registry
  • 217087-09-7
FDA_UNII_Code
  • R6DXU4WAY9
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that blocks acid from being made in the stomach. It is used to treat acid reflux disease and to prevent certain types of gastrointestinal ulcers. Esomeprazole magnesium is being studied in the prevention of esophageal cancer and in the treatment of other conditions, including side effects of chemotherapy. It is a type of anti-ulcer agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 367246
PDQ_Closed_Trial_Search_ID
  • 367246
Chemical_Formula
  • 2C17H18N3O3S.Mg.3H2O
Legacy_Concept_Name
  • Esomeprazole_Magnesium
FULL_SYN
  • Esomeprazole MagnesiumPTNCI
  • ESOMEPRAZOLE MAGNESIUMPTFDAR6DXU4WAY9
  • NexiumPTNCI-GLOSSCDR0000539482
  • NexiumBRNCI
  • Esomeprazole MagnesiumPTDCP50668
  • esomeprazole magnesiumPTNCI-GLOSSCDR0000539481
DEFINITION
  • The magnesium salt of esomeprazole, the S-isomer of omeprazole, with gastric proton pump inhibitor activity. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell.NCI
code
  • C29032
sameAs
is Has_Salt_Form of
is sameAs of
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