About: Ketorolac Tromethamine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Ketorolac Tromethamine
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ketorolac Tromethamine
UMLS_CUI
  • C0146226
CAS_Registry
  • 74103-07-4
FDA_UNII_Code
  • 4EVE5946BQ
Contributing_Source
  • FDA
Chemical_Formula
  • C15H13NO3.C4H11NO3
Legacy_Concept_Name
  • Ketorolac_Tromethamine
FULL_SYN
  • Ketorolac TromethaminePTNCI
  • KETOROLAC TROMETHAMINEPTFDA4EVE5946BQ
  • ToradolBRNCI
DEFINITION
  • The tromethamine salt of ketorolac, a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. Ketorolac tromethamine, a non-selective inhibitor of the cyclooxygenases (COX), inhibits both COX-1 and COX-2 enzymes. This agent exerts its anti-inflammatory effect by preventing conversion of arachidonic acid to prostaglandins at inflammation site mediated through inhibition of COX-2, which is undetectable in most tissues but is up-regulated at the inflammation sites. Since COX-1 is expressed virtually in all tissues, inhibition of COX-1 enzyme by this agent prevents normal state production of prostaglandins, which plays housekeeping roles in the protection of the gastrointestinal tract, regulating renal blood flow, and functioning in platelet aggregation. As a result, inhibition of COX-1 is usually associated with adverse effects such as gastrointestinal toxicity and nephrotoxicity.NCI
code
  • C61798
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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