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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ketorolac
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Ketorolac
UMLS_CUI
  • C0073631
CAS_Registry
  • 74103-06-3
FDA_UNII_Code
  • YZI5105V0L
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 40569
PDQ_Closed_Trial_Search_ID
  • 40569
Chemical_Formula
  • C15H13NO3
Legacy_Concept_Name
  • Ketorolac
FULL_SYN
  • KetorolacPTDCP30559
  • KETOROLACPTFDAYZI5105V0L
  • KetorolacPTNCI
  • ketorolacPTNCI-GLOSSCDR0000045305
DEFINITION
  • A synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic, and antipyretic activities. Ketorolac non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2. The inhibition of COX-2, up-regulated at sites of inflammation, prevents conversion of arachidonic acid to pro-inflammatory prostaglandins. The inhibition of COX-1 by this agent prevents the normal steady-state production of prostaglandins that play housekeeping roles in the protection of the gastrointestinal tract, the regulation of renal blood flow, and platelet aggregation. As a result, the inhibition of COX-1 may be associated with gastrointestinal toxicity, nephrotoxicity, and the inhibition of platelet aggregation.NCI
code
  • C1219
sameAs
http://linked.open...y/mesh/hasConcept
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