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AttributesValues
rdf:type
rdfs:label
  • Cefuroxime
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Cefuroxime
UMLS_CUI
  • C0007562
CAS_Registry
  • 55268-75-2
FDA_UNII_Code
  • O1R9FJ93ED
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16N4O8S
Legacy_Concept_Name
  • Cefuroxime
CHEBI_ID
  • CHEBI:3515
FULL_SYN
  • CEFUROXIMEPTFDAO1R9FJ93ED
  • CefuroximePTNCI
DEFINITION
  • A semisynthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin with antibacterial activity. Cefuroxime binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.NCI
code
  • C61669
sameAs
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