About: Cediranib Maleate

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About: Cediranib Maleate Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Cediranib Maleate
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b643527 nodeID://b643528 nodeID://b643529 nodeID://b643530
Has_Free_Acid_Or_Base_Form	Cediranib
Has_Target	Vascular Endothelial Growth Factor Receptor-1 Fms-Related Tyrosine Kinase 3 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factor Receptor-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Cediranib Maleate
NSC_Code	732208
UMLS_CUI	C1541530
CAS_Registry	857036-77-2
FDA_UNII_Code	68AYS9A614
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. Cediranib maleate may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of antiangiogenesis agent and a type of vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	425596
PDQ_Closed_Trial_Search_ID	425596
Chemical_Formula	C25H27FN4O3.C4H4O4
Legacy_Concept_Name	AZD2171
FULL_SYN	cediranib maleatePTNCI-GLOSSCDR0000597183 AZD2171 MaleateSYNCI AZD2171PTNCI-GLOSSCDR0000430872 Cediranib MaleatePTNCI CEDIRANIB MALEATEPTFDA68AYS9A614 RecentinPTNCI-GLOSSCDR0000597182 RecentinFBNCI Quinazoline, 4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxy-7-(3-(1-pyrrolidinyl)propoxy)-SNNCI
DEFINITION	The maleate salt of an indole ether quinazoline derivative with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.NCI
code	C48379
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0496486
is Has_Salt_Form of	Cediranib

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