About: Dasatinib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Dasatinib
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b648985 nodeID://b648986 nodeID://b648987 nodeID://b648988 nodeID://b648989
Has_Target	Fusion Proteins, bcr-abl Proto-Oncogene Proteins c-kit Tyrosine-Protein Kinase CSK Ephrin Type-A Receptor 2 Receptor, Platelet-Derived Growth Factor beta
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Dasatinib
NSC_Code	732517
UMLS_CUI	C1455147
CAS_Registry	863127-77-9
Accepted_Therapeutic_Use_For	Chronic myeloid leukemia; Philadelphia chromosome-positive acute lymphoblastic leukemia
FDA_UNII_Code	RBZ1571X5H
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of chronic myeloid leukemia and acute lymphoblastic leukemia. BMS-354825 is also being studied in the treatment of certain other blood diseases and types of cancer. BMS-354825 binds to and blocks BCR-ABL and other proteins that help cancer cells grow. It is a type of tyrosine kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	315885
PDQ_Closed_Trial_Search_ID	315885
Chemical_Formula	C22H26ClN7O2S.H2O
Legacy_Concept_Name	BMS-354825
FULL_SYN	DasatinibPTDCP32181 DASATINIBPTFDARBZ1571X5H SprycelPTNCI-GLOSSCDR0000508645 SprycelBRNCI BMS-354825PTNCI-GLOSSCDR0000340926 DasatinibPTNCI BMS-354825CNNCI dasatinibPTNCI-GLOSSCDR0000484435
DEFINITION	An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.NCI
code	C38713
sameAs	DASATINIB DASATINIB
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0470497
is sameAs of	DASATINIB DASATINIB DASATINIB

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