About: Diclofenac     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diclofenac
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Diclofenac
UMLS_CUI
  • C0012091
CAS_Registry
  • 15307-86-5
FDA_UNII_Code
  • 144O8QL0L1
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.NCI-GLOSS
Chemical_Formula
  • C14H11Cl2NO2
Legacy_Concept_Name
  • Diclofenac
CHEBI_ID
  • CHEBI:47381
FULL_SYN
  • diclofenacPTNCI-GLOSSCDR0000617659
  • 2-[(2,6-Dichlorophenyl)amino]benzeneacetic AcidSNNCI
  • DICLOFENACPTFDA144O8QL0L1
  • DiclofenacPTNCI
DEFINITION
  • A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)NCI
code
  • C28985
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 18 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software