About: Benzoylphenylurea     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Benzoylphenylurea
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Benzoylphenylurea
NSC_Code
  • 639829
UMLS_CUI
  • C0935907
In_Clinical_Trial_For
  • Unspecified solid tumors
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of antitubulin agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38213
PDQ_Closed_Trial_Search_ID
  • 38213
Legacy_Concept_Name
  • Benzoylphenylurea
FULL_SYN
  • BPUPTNCI-GLOSSCDR0000044374
  • benzoylphenylureaPTNCI-GLOSSCDR0000045004
  • BPUABNCI
  • BenzoylphenylureaPTNCI
DEFINITION
  • A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04)NCI
code
  • C2618
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