About: Colchicine-Site Binding Agent     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Colchicine-Site Binding Agent
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Colchicine-Site Binding Agent
UMLS_CUI
  • C1880116
Legacy_Concept_Name
  • Colchicine-Site_Binding_Agent
FULL_SYN
  • Colchicine-Site Binding AgentPTNCI
  • Colchicine-Site Binding AgentsSYNCI
DEFINITION
  • An anti-mitotic compound that binds to the beta tubulin subunit at the N-terminal domain (within residues 1-41) and within residues 214-241. Agents binding at the colchicine site produce a conformational change in the protofilament structure which subsequently impairs the polymerization of tubulin dimers and thereby prevents the formation of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, leading to cell cycle arrest and/or apoptosis.NCI
code
  • C67421
is rdfs:subClassOf of
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