About: Apoptosis Regulator Bcl-2     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Apoptosis Regulator Bcl-2
equivalentClass
OMIM_Number
  • 151430
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Apoptosis Regulator Bcl-2
UMLS_CUI
  • C0597712
ALT_DEFINITION
  • A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying.NCI-GLOSS
Legacy_Concept_Name
  • B-Cell_CLL_Lymphoma-2
FULL_SYN
  • BCL2PTNCI-GLOSSCDR0000613897
  • BCL-2 ProteinSYNCI
  • Apoptosis Regulator Bcl-2PTNCI
  • BCL2SYNCI
  • B-cell leukemia/lymphoma 2 proteinPTNCI-GLOSSCDR0000613899
  • B-Cell CLL/lymphoma 2SYNCI
Swiss_Prot
  • P10415
DEFINITION
  • Apoptosis regulator Bcl-2 (239 aa, ~26 kDa) is encoded by the human BCL2 gene. This protein plays a role in cellular survival.NCI
DesignNote
  • A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells. Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M. BCL-2 regulates cell death by controlling mitochondrial membrane permeability. Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity. Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas. (from OMIM 151430 and NCI)
code
  • C18115
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