About: Paclitaxel

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Paclitaxel
equivalentClass	nodeID://b636766
Has_Target	Tubulin Apoptosis Regulator Bcl-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Paclitaxel
NSC_Code	125973 673089
UMLS_CUI	C0144576
CAS_Registry	33069-62-4
Accepted_Therapeutic_Use_For	AIDS-related Kaposi's sarcoma; Bladder cancer; Breast cancer; Cervical cancer; Endometrial adenocarcinoma; Esophageal cancer; Head and Neck cancer; Lung cancer; non-small cell; Lymphoma; Ovarian cancer; Prostate cancer; Testicular cancer
In_Clinical_Trial_For	Bladder cancer; Breast cancer; Cervical cancer; Endometrial cancer; Esophageal cancer; Fallopian cancer; Glioma; Lymphoma; Non-small cell lung cancer; Ovarian cancer; Prostate cancer; Renal cell cancer; Unspecified solid tumors; Thymoma
FDA_UNII_Code	P88XT4IS4D
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used together with another drug to treat non-small cell lung cancer. Paclitaxel is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39762
PDQ_Closed_Trial_Search_ID	39762
Chemical_Formula	C47H51NO14
Legacy_Concept_Name	Paclitaxel
CHEBI_ID	CHEBI:45863
FULL_SYN	[2aR-[2a Alpha,4beta,4a beta,6beta,9alpha(alphaR,betaS),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl EsterSNNCI 5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserineSNNCI paclitaxelPTNCI-GLOSSCDR0000045258 TaxolPTNCI-GLOSSCDR0000507554 Taxol KonzentratFBNCI TaxolPTDCP20474 TaxolBRNCI PraxelFBNCI AsotaxFBNCI AnzataxFBNCI PACLITAXELPTFDAP88XT4IS4D PaclitaxelSYDTPNSC0125973 BristaxolFBNCI PaclitaxelPTNCI
DEFINITION	A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)NCI
code	C1411
sameAs	PACLITAXEL PACLITAXEL
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0026156
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