About: Docetaxel

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Docetaxel
equivalentClass	nodeID://b632020
Has_Target	Tubulin Apoptosis Regulator Bcl-2 Vascular Endothelial Growth Factor A
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Docetaxel
NSC_Code	628503
UMLS_CUI	C0246415
CAS_Registry	148408-66-6
Accepted_Therapeutic_Use_For	Breast cancer; Esophageal cancer; Gastric cancer; Head/Neck cancers; Locally Advanced or Metastatic Non small-cell lung cancer; Ovarian cancer; Metastatic Prostate cancer
In_Clinical_Trial_For	Non-Small-Cell Lung cancer; Osteosarcoma; Ovarian cancer; Pancreatic cancer; Penile cancer; Prostate cancer; Breast cancer; Cervical cancer; Fallopian tube cancer; Peritoneal cavity cancer; Endometrial cancer Acute lymphoblastic leukemia; Acute myeloid leukemia; Breast cancer; Cervical cancer; Chondrosarcoma; Esophageal cancer; Ewing's sarcoma; Gastric cancer; Head and Neck cancer; Colorectal cancer; Solid tumors
FDA_UNII_Code	15H5577CQD
Contributing_Source	FDA
ALT_DEFINITION	A drug used together with other drugs to treat certain types of breast cancer, stomach cancer, prostate cancer, and certain types of head and neck cancer. It is also being studied in the treatment of other types of cancer. Docetaxel is a type of mitotic inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41657
PDQ_Closed_Trial_Search_ID	41657
Chemical_Formula	C43H53NO14.3H2O
Legacy_Concept_Name	Docetaxel
CHEBI_ID	CHEBI:59809
FULL_SYN	N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxolSNNCI DocetaxelPTDCP32090 [2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR,betaS),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl EsterSNNCI TaxotereSYDTPNSC0628503 DOCETAXELPTFDA15H5577CQD RP56976CNNCI TaxoterePTNCI-GLOSSCDR0000508678 TaxotereBRNCI Taxotere Injection ConcentrateBRNCI DocetaxelPTNCI docetaxelPTNCI-GLOSSCDR0000045382
DEFINITION	A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)NCI
code	C1526
sameAs	DOCETAXEL DOCETAXEL
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0184558
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