About: The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy

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About: The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy Goto Sponge NotDistinct Permalink

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	Research in biomedicine, particularly in cell biology and pathology, genotoxicology, teratology and neuroscience. Development and verification of analytical, diagnostic and therapeutic methods, based on the results of basic research in these fields. The research will be oriented to the molecular and cellular basis of human diseases, mainly those which arise as a result of the effects of negative environmental factors and the aquisition and differentiation of stem cells. The study will be concentrated on the pathological changes produced by unfavourable physical and chemical factors in the cell genome, cells and tissues during embryonal development and aging, autoimmune and demyelinating diseases and brain ischemia. The results will contribute to an understanding of the mechanisms of information processing within a cell, in the neuronal circuits of the CNS and in the extracellular space of the brain and to an understanding of their changes in human diseases. (en) Výzkum v biomedicíně zejména v buněčné biologii a patologii, genotoxikologii a teratologii, neurofyziologii, neuroanatomii a neurochemii. Vývoj a ověřování analytických, diagnostických a terapeutických metod, založených na výsledcích základního výzkumu v těchto oborech. Výzkum bude zaměřen na molekulární a buněčné základy humánních onemocnění, především těch, která vznikají negativním působením civilizačních faktorů a na získání a kontrolu diferenciace kmenových buněk. Budou studovány patologické změny v genomu buňky, v buňkách a tkáních v průběhu embryonálního vývoje, stárnutí, změny vyvolané působením nepříznivých fyzikálních a chemických faktorů a změny v průběhu autoimunitních a demyelinizačních onemocnění a ischemie mozku. Výsledkem výzkumu bude objasnění mechanismů přenosu a zpracování informace uvnitř buňky, v nervových okruzích CNS a extracelulárním prostoru mozku a míchy a objasnění změn, které vznikají v průběhu patologických procesů.
Title	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy (en) Molekulární a buněčné základy vybraných onemocnění lidského organismu, mechanismy normální a patologické funkce, principy diagnostiky a léčby
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5039906/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5039906/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2005-06-17 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ%2F2005%2FAV0%2FAV0500%2FU%2FN%2F3%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33123766
http://linked.open...ai/cez/hlavniObor	EA - Morfologické obory a cytologie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	biomedicine;cell biology;genotoxicology;teratology;neuroscience;diagnosis;therapy;disease;environmental;pathological changes;embryonal development;aging;brain;genome;autoimmune and demyelimization diseases;physical and chemical factors (en)
http://linked.open...icUkonceniPodpory	1 (xsd:int)
http://linked.open...icZahajeniPodpory	1 (xsd:int)
http://linked.open...cez/partnerHlavni	Ústav experimentální medicíny Akademie věd České republiky, v. v. i.
http://linked.open...z/poceVysledkuRIV	448 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	448 (xsd:int)
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...okUkonceniPodpory	2004
http://linked.open...okZahajeniPodpory	1999
http://linked.open...iciPoslednihoRoku	2005
http://linked.open...atUdajeProjZameru	2005
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open.../cez/vedlejsiObor	EB - Genetika a molekulární biologie FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Dosažené výsledky v oblasti neurověd, buněčné biologie, genotoxikologie, kmenových buněk, teratologie a farmakologie přispěly k objasnění mechanismů řady humánních onemocnění a budou využity v klinické praxi při vývoji nových terapeutických postupů. (cs) Results in the fields of neuroscience, cell biology, genotoxicology, stem cells, teratology and pharmacology helped to elucidate the mechanisms of human diseases and will be used in clinical practice for the development of new therapeutic approaches. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Walking alongside the nucleoskeleton. Volume transmission in health and disease: communication via the brain extracellular space. Význam alterací adhezivních molekul CD44 v maligním chování nádorů. Cytogenetic Markers, DNA Single-Strand Breaks, Urinary Metabolites, and DNA Repair Rates in Styrene-Exposed Lamination Workers Cytogenetic analysis using fluorescence in situ hybridization (FISH) to evaluate occupational exposure to carcinogens Derivation and characterization of new human embryonic stem cells in Czech Republic Development of the inner ear in Splotch mutant mice Cytogenetic analysis and occupational health in the Czech Republic. Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA Glutamate-Evoked Alterations of Glial and Neuronal Cell Morphology in the Guinea Pig Retina Green fluorescent protein bone marrow cells express hematopoietic and neural antigens in culture and migrate within the neonatal rat brain The genotoxic effect of carcinogenic PAHs, their artificial and environmental mixtures (EOM), on human diploid lung fibroblasts Genotoxicity of environmental air pollution in three European cities: Prague, Košice and Sofia Global Nature of Dynamics Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant Magnetic resonance tracking of transplanted bone marrow and embryonic stem cells labeled by iron oxide nanoparticles in rat brain and spinal cord The microarchitecture of DNA replication domains Functional structure of the cell nucleus 7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene by inhalation Genetic polymorphisms and possible gene-gene interactions in metabolic and DNA repair genes: Effect on DNA damage Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 4: Growth of rat bone marrow stromal cells in three-dimensional hydrogels with positive and negative surface charges and in polyelectrolyte complexes Neural differentiation of pluripotent mouse embryonal carcinoma cells by retinoic acid - inhibitory effect of serum Retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells is potentiated by leukemia inhibitory factor Abnormal development of mouse embryoid bodies lacking p27Kip1 cell cycle regulator. Glia and Extracellular Space Diffusion Parameters in the Injured and Aging Brain. Glial diffusion barriers during aging and pathological states. Glutamate, NMDA and AMPA Induced Changes in Extracellular Space Volume and Tortuosity in the Rat Spinaal Cord. Embryotoxicity of TPPS4 and PS 3 photosensitizers in chicken embryo under different light conditions. Embryotoxicity of 1,2-Dibromoethane in chick embryos in ovo: early and late effects. Functional characteristics of neurons in the auditory thalamus. Epiteolidní hemangioendoteliom jater (kazuistika). Extracellular space volume fraction and geometry in human cortex and glial tumors. Extracellular space size and geometry in the brain of APP23 mice representing a model of Alzheimer s disease. Kinetics of formation of specific styrene oxide adducts in double-stranded DNA Lihgt irradiation increases embryotoxicity of photodynamic therapy sensitizers (5-aminolevulinic acid and protoporphyrin IX) in chick ebryos. Kometový Test: Princip metody a klinické aplikace. Learning, MRI and structural changes of the rat hippocampus 1 ro 12 months after irradiation with the leksell gamma knife. Cochlear function in young and adult Fischer 344 rats Cystatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes. Clinical implementation of 4-dihydroxyborylphenylalanine synthesised by an asymetric pathway. Increased apoptosis in differentiating p27-deficient mouse embryonic stem cells Immunolocalization of Upstream binding factor and pocket protein p130 during final stages of bovine oocyte growth Impact of phase I or phase II enzyme polymorphisms on lymphocyte DNA adducts in subjects exposed to urban air pollution and environmental tobacco smoke Infiltration of ambient PM2.5 and levels of indoor generated non-ETS PM2.5 in residences of four European cities Inhibitory control at a synaptic relay Vitamin C, E and A levels in maternal and fetal blood for Czech and Gypsy ethnic groups in the Czech Republic. A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice. The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells. A promoter genotype and oxidative stress potentially link resistin to human insulin resistance. Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice FGF-2 expression and its action in human leukemia and lymphoma cell lines. Fish analysis of chromosome breakage as biomarker of genotoxicity of urban air pollution. Epithelial Histo-Morphogenesis during odontogenesis in the mouse and role of the mesenchyme. Oldies but goldies: searching for Christmas trees within the nucleolar architecture. Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea Activation mechanism of the heterodimeric GABAB receptor Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II Formation of Nuclear Splicing Factor Compartments Is Independent of Lamins A/C Extracellular matrix and diffusion barriers in human astrocytic tumors Extrasynaptic Volume Transmission and Diffusion Parameters of the Extracellular Space. Extracellular matrix glycoproteins and diffusion barriers in human astrocytic tumours FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells The EXPOLIS study: implications for exposure research and environmental policy in Europe The nucleolus and transcription of ribosomal genes

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