About: Effect of endocrine disruptors on mammalian fertlity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality. Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality. (en)
Title	Effect of endocrine disruptors on mammalian fertlity Effect of endocrine disruptors on mammalian fertlity (en)
skos:prefLabel	Effect of endocrine disruptors on mammalian fertlity Effect of endocrine disruptors on mammalian fertlity (en)
skos:notation	RIV/86652036:_____/08:00323287!RIV11-MSM-86652036
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06011), P(2B06151), P(OE 211), Z(AV0Z5039906), Z(AV0Z50520701), Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Pěknicová, Jana Nováková, Vendula
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biotechnologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	365068
http://linked.open...ai/riv/idVysledku	RIV/86652036:_____/08:00323287
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	endocrine disruptor; mammalian fertility; spermatozoa (en)
http://linked.open.../riv/klicoveSlovo	endocrine disruptor spermatozoa mammalian fertility
http://linked.open...ontrolniKodProRIV	[A81F95E610F7]
http://linked.open...v/mistoKonaniAkce	Moskva
http://linked.open...i/riv/mistoVydani	Moskva
http://linked.open...i/riv/nazevZdroje	Book of abstract
http://linked.open...in/vavai/riv/obor	DN
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biodegradation of polybrominated compounds, monitoring of concentration changes of pollutants and their intermediates in the environment The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment. http://linked.opendata.cz/resource/domain/vavai/projekt/OE%20211
http://linked.open...UplatneniVysledku	2008
http://linked.open...iv/tvurceVysledku	Pěknicová, Jana Nováková, Vendula Boubelík, Michael Buckiová, Daniela
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2008-06-30 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Establishing of the Biotechnology Institute ASCR The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Medi Expo
https://schema.org/isbn	978-5-94943-043-9
is http://linked.open...avai/riv/vysledek of	Effect of endocrine disruptors on mammalian fertlity Effect of endocrine disruptors on mammalian fertlity Effect of endocrine disruptors on mammalian fertlity

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