About: T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription. Death receptor-6 (DR6) participates in the regulation of T-cell activation and/or activity as its genetic disruption results in enhanced CD4+ T-cell expansion, the production of Th2 cytokines, and interestingly also the compromised migration of CD4+ T cells to sites of inflammation. In this communication we show that DR6 is not expressed in resting T cells from human peripheral blood or murine lymph nodes but that its expression is significantly upregulated in CD3 crosslinking- or PMA/ionomycin-activated T lymphocytes. DR6 expression is transiently increased in both activated human CD4+ and CD8+ T cells and it is apparently dependent on the activation of NF-kappaB and NF-AT signaling pathways. In contrast to primary peripheral blood T cells, the widely used model lymphoblastic leukemia T-cell line Jurkat is DR6-positive and unexpectedly, TCR-mediated stimulation of Jurkat cells strongly downregulates DR6 expression via suppression of its transcription. (en)
Title	T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner (en)
skos:prefLabel	T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner (en)
skos:notation	RIV/68378050:_____/11:00371708!RIV12-AV0-68378050
http://linked.open...avai/predkladatel	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	12-13
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Koc, Michal Anděra, Ladislav Broučková, Adéla Klíma, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	234264
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00371708
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TNFRSF21; T cells; Jurkat (en)
http://linked.open.../riv/klicoveSlovo	Jurkat TNFRSF21 T cells
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[9F3A07B3D416]
http://linked.open...i/riv/nazevZdroje	Molecular Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Molecular and Cellular Immunology
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	48
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Koc, Michal Broučková, Adéla Klíma, Martin
http://linked.open...ain/vavai/riv/wos	000292444100011
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0161-5890
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molimm.2011.03.021
is http://linked.open...avai/riv/vysledek of	T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner T-cell activation triggers death receptor-6 expression in a NF-kappa B and NF-AT dependent manner

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