About: Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	PML tumor suppressor is upregulated in several forms of cellular senescence, however the mechanism of its induction is elusive. Here we show that genotoxic drugs that induce senescence, such as bromodeoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin evoke expansion of PML nuclear compartment and its association with persistent DNA lesions in several human normal and cancer cells. This phenomenon was accompanied by elevation of PML transcripts. Chemical inhibition of all JAK kinases and RNAi-mediated knock-down of JAK1 suppressed PML expression, implicating JAK/STAT-mediated signaling in regulation of the PML gene. Our data show that upregulation of the PML tumor suppressor in cellular senescence triggered by diverse drugs including clinically used anti-cancer chemotherapeutics relies on stimulation of PML transcription by JAK/STAT-mediated signaling, possibly evoked by the autocrine/paracrine activities of senescence-associated cytokines. PML tumor suppressor is upregulated in several forms of cellular senescence, however the mechanism of its induction is elusive. Here we show that genotoxic drugs that induce senescence, such as bromodeoxyuridine, thymidine, distamycin A, aphidicolin, etoposide and camptothecin evoke expansion of PML nuclear compartment and its association with persistent DNA lesions in several human normal and cancer cells. This phenomenon was accompanied by elevation of PML transcripts. Chemical inhibition of all JAK kinases and RNAi-mediated knock-down of JAK1 suppressed PML expression, implicating JAK/STAT-mediated signaling in regulation of the PML gene. Our data show that upregulation of the PML tumor suppressor in cellular senescence triggered by diverse drugs including clinically used anti-cancer chemotherapeutics relies on stimulation of PML transcription by JAK/STAT-mediated signaling, possibly evoked by the autocrine/paracrine activities of senescence-associated cytokines. (en)
Title	Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling (en)
skos:prefLabel	Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling (en)
skos:notation	RIV/68378050:_____/10:00347137!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/1418), P(GA301/08/0353), P(IAA500390501), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	15
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Nováková, Zora Dušková, Pavlína Blažková, Hana Vančurová, Markéta Hodný, Zdeněk Košař, Martin Hubáčková, Soňa Krejčíková, Kateřina Dobrovolná, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	284511
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00347137
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PML tumor suppressor; cellular senescence; JAK-STAT signaling pathway (en)
http://linked.open.../riv/klicoveSlovo	cellular senescence JAK-STAT signaling pathway PML tumor suppressor
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[1FB82CEC615B]
http://linked.open...i/riv/nazevZdroje	Cell Cycle
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of the JAK/STAT signalling pathway in cellular senescence Protein modifications in DNA damage signalling: Mechanisms and cancer relevance The role of PML in cellular senescence
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Hodný, Zdeněk Hubáčková, Soňa Košař, Martin Krejčíková, Kateřina Hanzlíková, Hana Nováková, Zora Dobrovolná, Jana Dušková, Pavlína Vančurová, Markéta Barath, P. Bartek, J.
http://linked.open...ain/vavai/riv/wos	000281206300038
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1538-4101
number of pages	15 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling Regulation of the PML tumor suppressor in drug-induced senescence of human normal and cancer cells by JAK/STAT-mediated signaling

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 84 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software