| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Již dříve bylo zjištěno, že kyselina alfa-lipoová (LA) zrychluje hojení ran u pacientů s chronickými ranami, kteří byli podrobeni léčbě hyperbarickým kyslíkem (HBO). Jelikož proteinázy jsou pro hojení ran důležité, vytvořili jsme hypotézu, že LA reguluje expresi matrix metalloproteinázy (MMP) v buňkách účastnících se hojení. Pacienti podrobení HBO terapii byli náhodně s dvojitým zaslepením rozděleni do dvou skupin, LA a placebo. Expresní profily pro MMP a pro mediátory angiogenezy byly určeny v bioopsiích odebraných při prvním a sedmém působení HBO, a po 14 dnech jeho působení. ELISA testy byly použity k ověření exprese vybraných genů pomocí microarray. Přidání LA v kombinaci s HBO terapií způsobilo snížení hladin zánětlivých cytokinů a růstových faktorů, které posléze ovlivnily expresi MMP. Přerušení pozitivní autokrinní zpětné vazby, která udržuje rány v chronickém stavu, podporuje postup procesu hojení. (cs)
- alpha-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair we hypothesized that LA may regulate matrix metalloproteinase (MMP) expression in cells involved in wound repair. Patients undergoing HBO therapy were double-blind randomized into two groups: LA group and placebo group. Gene expression profiles for MMPs and for angiogenesis mediators were evaluated in biopsies collected at the first HBO session, at the seventh HBO session, and after 14 days of HBO treatment. ELISA tests were used to validate microarray expression of selected genes. LA supplementation in combination with HBO therapy downregulated the inflammatory cytokines and the growth factors which, in turn, affect MMPs expression. The disruption of the positive autocrine feedback loops that maintain the chronic wound state promotes progression of the healing process.
- alpha-Lipoic acid (LA) has been found previously to accelerate wound repair in patients affected by chronic wounds who underwent hyperbaric oxygen (HBO) therapy. Because proteinases are important in wound repair we hypothesized that LA may regulate matrix metalloproteinase (MMP) expression in cells involved in wound repair. Patients undergoing HBO therapy were double-blind randomized into two groups: LA group and placebo group. Gene expression profiles for MMPs and for angiogenesis mediators were evaluated in biopsies collected at the first HBO session, at the seventh HBO session, and after 14 days of HBO treatment. ELISA tests were used to validate microarray expression of selected genes. LA supplementation in combination with HBO therapy downregulated the inflammatory cytokines and the growth factors which, in turn, affect MMPs expression. The disruption of the positive autocrine feedback loops that maintain the chronic wound state promotes progression of the healing process. (en)
|
| Title
| - alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy
- alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy (en)
- Kyselina alfa-lipoová moduluje expresi genů pro extracelulární matrix a angiogenezu v nehojících se ranách léčených hyperbarickou kyslíkovou terapií (cs)
|
| skos:prefLabel
| - alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy
- alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy (en)
- Kyselina alfa-lipoová moduluje expresi genů pro extracelulární matrix a angiogenezu v nehojících se ranách léčených hyperbarickou kyslíkovou terapií (cs)
|
| skos:notation
| - RIV/68378050:_____/08:00318820!RIV09-AV0-68378050
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - Z(AV0Z50520514), Z(AV0Z50520701)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00318820
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - angiogenesis mediators; wound repair; matrix metalloproteinase expression (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Alleva, R.
- Borghi, B.
- Emanuelli, M.
- Neužil, Jiří
- Santarelli, L.
- Sartini, D.
- Tomasetti, M.
- Di Donato, F.
- Nasole, E.
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| is http://linked.open...avai/riv/vysledek
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)