| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Membránové mikrodomény obohacené cholesterolem, jako jsou caveoly, regulují asociaci protein kinas rodiny Src (SFK) s PDGF-receptorem (PDGFR), která je potřebná pro mitogenní signalizaci. PAG, široce exprimovaný transmembránový adaptorový protein, negativně reguluje SFK tím, že váže a aktivuje kinasu Csk. Bylo zjištěno, že PAG moduluje množství PRGFR v caveolách a mitogenní signalizaci pomocí mechanismu nezávislého na Csk. Tato regulace vyžaduje prvních N-terminálních 97 aa PAG 9PAG-N). PAG-N zvyšuje množství gangliosidu GM1 na buněčném povrchu a vytěsňuje GM1 z caveol. Tento proces vyžaduje sialidasu Neu-3. PAG tedy reguluje distribuci PDGFR a mitogenní aktivitu SFK tím, že moduluje GM1 v caveolách nezávisle na Csk. (cs)
- Cholesterol-enriched membrane domains, such as caveolae, regulate association of SRC family protein tyrosine kinases (SFK) with the platelet-derived growth factor receptor (PDGFR), which is needed for mitogenic signaling. PAG, a ubiquitously expressed member of the transmembrane adaptor protein family, is known to negatively regulate SFK signaling though binding to Csk. PAG was found to modulate PDGFR levels in caveolae and SFK mitogenic signaling through a Csk-independent mechanism. Regulation of SFK mitogenic activity by PAG requires the first N-terminal 97 aa (PAG-N), which include the extracellular and transmembrane domains, palmitoylation sites, and a short cytoplasmic sequence. PAG-N increases ganglioside GM1 levels at the cell surface and, thus, displaces PDGFR from caveolae, a process that requires the ganglioside-specific sialidase Neu-3. PAG regulates PDGFR membrane partitioning and SFK mitogenic signaling by modulating GM1 levels within caveolae independently from Csk.
- Cholesterol-enriched membrane domains, such as caveolae, regulate association of SRC family protein tyrosine kinases (SFK) with the platelet-derived growth factor receptor (PDGFR), which is needed for mitogenic signaling. PAG, a ubiquitously expressed member of the transmembrane adaptor protein family, is known to negatively regulate SFK signaling though binding to Csk. PAG was found to modulate PDGFR levels in caveolae and SFK mitogenic signaling through a Csk-independent mechanism. Regulation of SFK mitogenic activity by PAG requires the first N-terminal 97 aa (PAG-N), which include the extracellular and transmembrane domains, palmitoylation sites, and a short cytoplasmic sequence. PAG-N increases ganglioside GM1 levels at the cell surface and, thus, displaces PDGFR from caveolae, a process that requires the ganglioside-specific sialidase Neu-3. PAG regulates PDGFR membrane partitioning and SFK mitogenic signaling by modulating GM1 levels within caveolae independently from Csk. (en)
|
| Title
| - The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
- The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1 (en)
- Csk-vážící protein PAG reguluje Src-indukovanou mitogenní signalizaci PDGF via GM1 (cs)
|
| skos:prefLabel
| - The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
- The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1 (en)
- Csk-vážící protein PAG reguluje Src-indukovanou mitogenní signalizaci PDGF via GM1 (cs)
|
| skos:notation
| - RIV/68378050:_____/08:00315261!RIV09-AV0-68378050
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0506), Z(AV0Z50520514)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/08:00315261
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - PDGF receptor; mitogenní aktivita; PAG (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hořejší, Václav
- Benistant, C.
- Richard, V.
- Roche, S.
- Schraven, B.
- Simon, V.
- Veracini, L.
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
| is http://linked.open...avai/riv/vysledek
of | |
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