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  • LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence of T cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors.
  • LIME is a transmembrane adaptor that associates with the Lck, Fyn and Csk. To delineate the role of LIME in vivo, LIME-deficient mice were generated. The absence of LIME impeded neither the development nor the function of B and T cells. TCR transgenic mice deprived of LIME showed, however, a 1.8-fold enhancement in positive selection. Since B cells and activated T cells express LIME and the related adaptor NTAL, mice lacking both adaptors were generated. Double-deficient mice showed no defect in the development and function of B and T cells, and the lack of LIME had no effect on the autoimmune syndrome that develops in aged NTAL-deficient mice. In contrast to a previous report, we further showed that this autoimmune syndrome develops in the absence of T cells. Therefore, our in vivo results demonstrate that LIME has no seminal role in the signaling cassette operated by antigen receptors and coreceptors. (en)
  • LIME je adaptorový protein, který asociuje s Lck, Fyn a Csk. Pro určení funkce tohoto proteinu byly připraveny LIME-deficientní myši. Absence LIME neměla vliv na vývoj a funkci B ani T lymfocytů. TCR transgenní myši s chybějícím LIME ale vykazovaly 1.8-násobné zvýšení pozitivní selekce. Byly připraveny také myši, kterým chyběl jak LIME, tak podobný adaptorový protein NTAL. Dvojitě deficientní myši měly normální vývoj a funkci B a T lymfocytů a nepřítomnost LIME neměla žádný vliv na autoimunitní syndrom, který se vyvíjí u starých NTAL-deficientních myší. na rozdíl od dřívější zprávy je ukázáno, že tento autoimunitní syndrom se vyvíjí i za absence T lymfocytů. Tyto in vivo výsledky ukazují, že, že LIME nemá žádný zásadní význam pro signalizační děje iniciované antigenními receptory a koreceptory. (cs)
Title
  • Deletion of the LIME adaptor protein minimally affects T and B cell development and function
  • Deletion of the LIME adaptor protein minimally affects T and B cell development and function (en)
  • Eliminace adaptorového proteinu LIME jen minimálně ovlivňuje vývoj a funkci T a B lymfocytů (cs)
skos:prefLabel
  • Deletion of the LIME adaptor protein minimally affects T and B cell development and function
  • Deletion of the LIME adaptor protein minimally affects T and B cell development and function (en)
  • Eliminace adaptorového proteinu LIME jen minimálně ovlivňuje vývoj a funkci T a B lymfocytů (cs)
skos:notation
  • RIV/68378050:_____/07:00093990!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 3259;3269
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0506), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 11
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 416118
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/07:00093990
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • LIME; adaptor protein; receptor (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV
  • [7C25C8965591]
http://linked.open...i/riv/nazevZdroje
  • European Journal of Immunology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 37
http://linked.open...iv/tvurceVysledku
  • Angelisová, Pavla
  • Hořejší, Václav
  • Wang, Y.
  • Šímová, Šárka
  • Simeoni, L.
  • Malissen, M.
  • Grégoire, C.
  • Malissen, B.
  • Burkhart, S.
  • Reinhold, D.
  • Richelme, S.
  • Sansoni, A.
  • Schmidr-Giese, A.
http://linked.open...n/vavai/riv/zamer
issn
  • 0014-2980
number of pages
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