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  • In this paper, we report an immunohistologic study of 6 transmembrane adaptor proteins and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies.
  • In this paper, we report an immunohistologic study of 6 transmembrane adaptor proteins and show that they are restricted to subpopulations of lymphoid cells, being present in either T cells (LAT, LIME, and TRIM), B cells (NTAL), or subsets of both cell types (PAG and SIT). Their expression in neoplastic lymphoid cells broadly reflects that of normal lymphoid tissue, including the positivity of plasma cells and myeloma/plasmacytoma for LIME, NTAL, PAG, and SIT. These molecules represent a potentially important addition to the panel of immunophenotypic markers detectable in routine biopsies that can be used in hematopathologic studies. (en)
  • Imunohistologická studie 6 transmembránovách adaptorových proteinů ukázala jejich omezenou expresi v lymfoidních buňkách (přítomnost v T-lymfocytech (LAT, LIME, TRIM), B-lymfocytech (NTAL) nebo subsetech těchto dvou typů (PAG, SIT)). Jejich exprese na neoplastických lymfoidních buňkách zhruba odráží expresi na odpovídajících normálních typech biněk, včetně pozitivity na plazmacytech a myelomech/plazmacytomech u LIME, NTAL, PAG a SIT. Tyto molekuly představují potenciálně další důležitý příspěvek do panelu imunofenotypických markerů detekovatelných v rutinních biopsiích, které mohou být použity v hematologických studiích. (cs)
Title
  • Transmembrane adaptor molecules: a new category of lymphoid-cell markers
  • Transmembránové adaptorové molekuly: nová kategorie markerů lymfoidních buněk (cs)
  • Transmembrane adaptor molecules: a new category of lymphoid-cell markers (en)
skos:prefLabel
  • Transmembrane adaptor molecules: a new category of lymphoid-cell markers
  • Transmembránové adaptorové molekuly: nová kategorie markerů lymfoidních buněk (cs)
  • Transmembrane adaptor molecules: a new category of lymphoid-cell markers (en)
skos:notation
  • RIV/68378050:_____/06:00027603!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 213;221
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0506), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 504244
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/06:00027603
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • transmembrane adaptors; PAG; LIME (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [E96717537460]
http://linked.open...i/riv/nazevZdroje
  • Blood
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 107
http://linked.open...iv/tvurceVysledku
  • Angelisová, Pavla
  • Hořejší, Václav
  • Rüdiger, T.
  • Sanchez, L.
  • Barry, R.
  • Du, M. Q.
  • Hansmann, M.-L.
  • Marafioti, T.
  • Masir, N.
  • Mason, D. Y.
  • Natkunam, Y.
  • Paterson, J. C.
  • Pileri, S.
  • Pozzobon, M.
  • Roberton, H.
  • Roncador, G.
  • Tedoldi, S.
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-4971
number of pages
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