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Description
| - Je popsáno minimálně 31 rodin lidských endogenních retrovirů (HERV), každá odvozená od nezávislé infekce exogenním virem. Dříve jsme pomocí důkazu čistící selekce na HERV genech popsali, že reinfekce replikačně kompetentního elementu byla hlavním mechanismem kopírování v některých rodinách. Zde analyzujeme evoluci 17ti HERV rodin pomocí poměru d(N)/d(S). Objevili jsme pozitivní korelaci mezi množstvím členů rodiny a dalšího kopírovacího mechanismu. všechny rodiny s více než 200 členy použili dodatečně jeden z těchto mechanismů: (1) trans komplementace (elementy jsou kopírovány členy stejné rodiny; HERV-H a ERV-9), (2) cis retrotranspozice (elementy se kopírují samy) v germinální linii (HERV-K(HML3)) a (3) kopírování nezávislé na HERV mašinerii. Rozebíráme, proč jsou tyto mechanismy vzácné ve většině rodin a proč je komplementace v trans významná pouze pro velké rodiny. (cs)
- There are at least 31 families of human endogenous retroviruses (HERVs), each derived from an independent infection by an exogenous virus. Using evidence of purifying selection on HERV genes, we have shown previously that reinfection by replication-competent elements was the predominant mechanism of copying in some families. Here we analyze the evolution of 17 HERV families using d(N)/d(S) ratios and find a positive relationship between copy number and the use of additional copying mechanisms. All families with more than 200 elements have also used one or more of the following mechanisms: (1) complementation in trans (elements copied by other elements of the same family; HERV-H and ERV-9), (2) retrotransposition in cis (elements copying themselves) within germ-line cells (HERV-K(HML3)), and (3) being copied by non-HERV machinery (HERV-W). We discuss why these other mechanisms are rare in most families and suggest why complementation in trans is significant only in the larger families.
- There are at least 31 families of human endogenous retroviruses (HERVs), each derived from an independent infection by an exogenous virus. Using evidence of purifying selection on HERV genes, we have shown previously that reinfection by replication-competent elements was the predominant mechanism of copying in some families. Here we analyze the evolution of 17 HERV families using d(N)/d(S) ratios and find a positive relationship between copy number and the use of additional copying mechanisms. All families with more than 200 elements have also used one or more of the following mechanisms: (1) complementation in trans (elements copied by other elements of the same family; HERV-H and ERV-9), (2) retrotransposition in cis (elements copying themselves) within germ-line cells (HERV-K(HML3)), and (3) being copied by non-HERV machinery (HERV-W). We discuss why these other mechanisms are rare in most families and suggest why complementation in trans is significant only in the larger families. (en)
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Title
| - High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection
- Vysoký počet lidských endogenních retrovirů v jednotlivých rodinách je asociován s kopírovacími mechanismy a reinfekcí (cs)
- High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection (en)
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skos:prefLabel
| - High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection
- Vysoký počet lidských endogenních retrovirů v jednotlivých rodinách je asociován s kopírovacími mechanismy a reinfekcí (cs)
- High copy number in human endogenous retrovirus families is associated with copying mechanisms in addition to reinfection (en)
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skos:notation
| - RIV/68378050:_____/05:00029060!RIV06-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(1M0520), Z(AV0Z50520514)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00029060
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - human endogenous retrovirus; reinfection; retrotransposition (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Molecular Biology and Evolution
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Pačes, Jan
- Belshaw, R.
- Burt, A.
- Katzourakis, A.
- Tristem, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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