About: Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia     Goto   Sponge   NotDistinct   Permalink

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Description
  • Patients with chronic lymphocytic leukemia (CLL) can relapse even after aggressive therapy. It is commonly assumed that to prevent relapse the level of minimal residual disease (MRD) should be as low as possible. We develop a robust and sensitive method for detection of the clonal immunoglobulin heavy-chain variable (IgV(H)) rearrangement in CLL and to introduce a highly sensitive and specific methodology for MRD monitoring in patients with CLL who undergo intensive treatment.
  • Patients with chronic lymphocytic leukemia (CLL) can relapse even after aggressive therapy. It is commonly assumed that to prevent relapse the level of minimal residual disease (MRD) should be as low as possible. We develop a robust and sensitive method for detection of the clonal immunoglobulin heavy-chain variable (IgV(H)) rearrangement in CLL and to introduce a highly sensitive and specific methodology for MRD monitoring in patients with CLL who undergo intensive treatment. (en)
  • Minimální zbytková choroba (MRD), tedy přetrvávání klonu leukemických buněk u pacientů po chemoterapii nebo transplantaci kmenových buněk je vážnou komplikací při léčbě. Byla vyvinuta rychlá, citlivá, spolehlivá a levná metoda detekce klonální přestavby v řetězci IgV(H), která usnadní sledování MRD u pacientů v průběhu léčby. Metoda využívá techniku RT-PCR s primery specifickými pro daného pacienta. (cs)
Title
  • Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia
  • Detekce přestavby IgV(H) pomocí “touch-down” RT-PCR a kvantifikace minimální residuální nemoci pomocí Sybr-Green RT-PCR v reálném čase u pacientů s chronickou lymfocytární leukemií (cs)
  • Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia (en)
skos:prefLabel
  • Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia
  • Detekce přestavby IgV(H) pomocí “touch-down” RT-PCR a kvantifikace minimální residuální nemoci pomocí Sybr-Green RT-PCR v reálném čase u pacientů s chronickou lymfocytární leukemií (cs)
  • Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia (en)
skos:notation
  • RIV/68378050:_____/05:00027994!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 23;34
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NM7604), Z(AV0Z50520514), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 546949
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/05:00027994
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • minimal residual disease; chronic lymphocytic leukaemia; IgV(H) rearrangement (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [2AA70FFCC28F]
http://linked.open...i/riv/nazevZdroje
  • Molecular Diagnosis
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 9
http://linked.open...iv/tvurceVysledku
  • Dvořák, Michal
  • Peková, Soňa
  • Marková, J.
  • Schwarz, J.
  • Cetkovský, P.
  • Pajer, Petr
http://linked.open...n/vavai/riv/zamer
issn
  • 1084-8592
number of pages
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