| Attributes | Values |
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| rdf:type
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| Description
| - NTAL a LAT jsou evolučně podobné transmembránové adaptorové proteiny, fosforylované během imunoreceptorové signalizace. Exprese LAT byla omezena na časná stádia B lymfocytů, zatímco NTAL byl charakteristický pro zralé B buňky. Ntal-deficientní myši byly zkříženy s Lat-deficientními myšmi. B buňky se vyvíjely v těchto dvojitě deficientních zvířatech normálně. Po BCR signalizaci vykazovaly Ntal(-/-) B buňky slabě sníženou mobilizaci Ca(2+) a proliferaci. Ntal-deficientní myši měly více přirozených protilátek a slabě zvýšené protilátkové odpovědi na T-dependentní antigen. Absence NTAL neměla vliv na hypergammaglobulinemii E a G1, která se vyvíjí u myší s mutací tyrosinu 136 LAT. NTAL tedy nehraje ve vývoji B lymfocytů podobnou roli jako LAT u T buněk. (cs)
- NTAL and LAT are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement. LAT expression was limited to early B cells, whereas NTAL expression typified mature B cells. Ntal-deficient mice were generated and crossed with Lat-deficient mice. B cells developed in Lat(-/-) Ntal(-/-) double-deficient mice with the same efficiency as in wild-type mice. Upon B-cell antigen receptor cross-linking, Ntal(-/-) B cells exhibited slightly increased Ca(2+) mobilization and proliferation. Ntal-deficient mice had increased levels of natural antibodies and slightly increased humoral response to a T-dependent antigen. Normal titers of serum-specific immunoglobulins were produced in response to a T-cell-independent antigen. NTAL absence did not affect the hypergammaglobulinemia E and G1 that developed in mice with a mutation in tyrosine 136 of LAT. Therefore, NTAL does not play a role in B cells symmetric to the role played by LAT in T cells.
- NTAL and LAT are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement. LAT expression was limited to early B cells, whereas NTAL expression typified mature B cells. Ntal-deficient mice were generated and crossed with Lat-deficient mice. B cells developed in Lat(-/-) Ntal(-/-) double-deficient mice with the same efficiency as in wild-type mice. Upon B-cell antigen receptor cross-linking, Ntal(-/-) B cells exhibited slightly increased Ca(2+) mobilization and proliferation. Ntal-deficient mice had increased levels of natural antibodies and slightly increased humoral response to a T-dependent antigen. Normal titers of serum-specific immunoglobulins were produced in response to a T-cell-independent antigen. NTAL absence did not affect the hypergammaglobulinemia E and G1 that developed in mice with a mutation in tyrosine 136 of LAT. Therefore, NTAL does not play a role in B cells symmetric to the role played by LAT in T cells. (en)
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| Title
| - Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function
- Jednotlivé a kombinované delece adaptorů NTAL/LAB a LAT minimálně ovlivňují vývoj a funkci B buněk (cs)
- Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function (en)
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| skos:prefLabel
| - Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function
- Jednotlivé a kombinované delece adaptorů NTAL/LAB a LAT minimálně ovlivňují vývoj a funkci B buněk (cs)
- Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function (en)
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| skos:notation
| - RIV/68378050:_____/05:00021315!RIV06-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(1M0506), Z(AV0Z50520514)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00021315
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| |
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Molecular and Cellular Biology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Angelisová, Pavla
- Hořejší, Václav
- Špička, Jiří
- Wang, Y.
- Horváth, Ondřej
- Schraven, B.
- Malissen, M.
- Hamm-Baarke, A.
- Grégoire, C.
- Guinamard, R.
- Malissen, B.
- Richelme, M.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
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| is http://linked.open...avai/riv/vysledek
of | |
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