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rdf:type
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Description
| - Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src-family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. LIME thus appears to be involved in regulation of T cell activation by co-receptors.
- Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src-family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. LIME thus appears to be involved in regulation of T cell activation by co-receptors. (en)
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Title
| - LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
- LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (en)
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skos:prefLabel
| - LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
- LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (en)
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skos:notation
| - RIV/68378050:_____/03:23033107!RIV/2004/AV0/A23004/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LN00A026), P(LN00A079), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:23033107
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - immunology; T-lymphocyte; adaptor protein (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Experimental Medicine
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Angelisová, Pavla
- Brdička, Tomáš
- Hořejší, Václav
- Pačes, Jan
- Špička, Jiří
- Horváth, Ondřej
- Hilgert, Ivan
- Schraven, B.
- Brdičková, Naděžda
- Simeoni, L.
- Kliche, S.
- Merten, C.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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