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| Description
| - The aim of the project is to elucidate molecular basis of key mechanisms regulating immune reactions under normal and pathological conditions, by means of basic research of lymphocyte antigen-specific receptors, receptors of certaincytokines and hormones and Fc-receptors. This research will be based on the hypothesis on a key role of supramolecular (domain) organization of plasma cell membrane and immunoreceptor interactions with cytoskeleton. With respectto essential physiological importance of these processes we expect that the results of our basic research will become a solid basis for development of reagents and procedures suitable for practical use in diagnostics and therapy of seriousimmunopathological disorders (allergies and other hypersensitivities, autoimmune and lymphoproliferative diseases). (en)
- Cílem projektu je objasnit molekulární podstatu klíčových mechanismů regulujících imunitní reakce za normálních a patologických okolností, a to především pomocí základního výzkumu zaměřeného na receptory lymfocytů pro antigeny,některé cytokiny a hormony a Fc-receptory. Tento výzkum bude založen na hypotéze o klíčové roli supramolekulární (doménové) organizace buněčné membrány a interakci imunoreceptorů s cytoskeletem. Vzhledem k zásadnífyziologické důležitosti zkoumaných procesů předpokládáme, že výsledky našeho základního výzkumu budou solidním základem pro vývoj látek a postupů vhodných pro praktické aplikace v diagnostice a terapii závažných imunopatologickýchporuch (např. alergie a jiné hypersensitivity, autoimunitní a některá lymfoproliferativní onemocnění).
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| Title
| - Center of molecular and cellular immunology (en)
- Centrum molekulární a buněčné imunologie
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - Membrane receptors; membrane microdomains; supramolecular organization; immunoreceptors; cytokines; hormones; cytoskeleton; immunopathological disorders (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - We discovered several new molecules playing roles in immune response and in pathological allergic reactions, and elucidated mechanisms responsible for rejection of corneal transplants. The results will serve for practical applications in diagnostics and (en)
- Bylo objeveno několik nových molekul, které hrají roli jak v imunitní odpovědi a v patologických alergických reakcích a objasněny mechanismy zodpovědné za odhojování transplantátů oční rohovky. Výsledky budou základem pro praktické aplikace v diagnostic (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - cytokines
- cytoskeleton
- hormones
- immunoreceptors
- membrane microdomains
- supramolecular organization
- Membrane receptors
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| is http://linked.open...vavai/riv/projekt
of | - Využití antigenem pulsovaných dendritických buněk k imnoregulacím.
- Corneal stromal cells selectively inbibit production of anti-inflamatory cytokines by activated T cells
- Corneal stromal cells selectively inhibit production of anti-inflammatory cytokines by activated T cells
- Gamma-tubulin in Leishmania: cell cycle-dependent changes in subcellular localization and heterogeneity of its isoform
- Hybridomové buňky produkující monoklonální protilátku specifickou pro protein STIM1
- Gamma-tubulin in Leishmania: cell cycle-dependent changes in subcellular localization and heterogeneity of its isoforms
- Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes
- Long-term agonist stimulation of IP prostanoid receptor depletes the cognate G(s)alpha protein in membrane domains but does not change the receptor level
- Prevention of corneal allograft rejection in a mouse model of hight risk recipients
- Prevention of corneal allograft rejection in a mouse model of high risk recipients
- Lipid rafts and their roles in T-cell activation
- The epitope recognized by pan-HLA class I-reactive monoclonal antibody W6/32 and its relationship to unusual stability of the HLA-B27/beta2-microglobulin complex.
- Lipid rafts in mast cell signalling
- The lipopolysaccharide coreceptor CD14 is present and functional in seminal plasma and expressed on spermatozoa.
- Lipid rafts and their role in signal transdiction - mant cells as a model.
- Delta-Opioid receptors exhibit high efficiency when activating trimeric G proteins in membrane domains.
- Combined spatial and enzymatic regulation of Csk by cAMP and protein kinase a inhibits T cell receptor signaling.
- Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.
- Constitutive excluslion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes.
- Increased baclofen-stimulated G protein coupling and deactivation in rat brain cortex during development
- Involvement of filamentous actin in setting the threshold for degranulation in mast cells
- I-mediated signaling events by Lyn kinase C-terminal tyrosine phosphorylation
- Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types.
- Vitamin E analogs:a new class of multiple action ogents with antineoplastic and anti-atherogenic activity.
- Altered myocardial Gs protein and adenylyl cyclase signaling in rats exposed to chronic hypoxia and normoxic recovery.
- A novel monoclonal reagent recognizing native and denatured Vbeta5.3-related chains of human T cell receptor.
- Exogenous administration of gangliosides inhibits Fc epsilon RI-mediated mast cell degranulation by decreasing the activity of phospholipase C gamma
- One-tube semi-nested PCR-ELISA for the detection of human cytomegalovirus DNA sequences: comparison with hybridization-based and semi-nested-based PCR-ELISA procedures.
- The 5th EFIS Tatra Immunology Conference on 'Molecular Determinants of T Cell Immunity' Held in the High Tatra Mountains, Slovakia, September 7-11, 2002.
- Změny v imunitě u pacientů závislých na heroinu a u klientů metadonového programu.
- A fast and simple dot-immunobinding assay for quantifiction of mouse immunoglobulins in hybridoma culture supernatants
- The alterations of immunological reactivity in heroin addicts and their normalization in patients maintained on methadone
- Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells
- NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation
- Prolonged agonist stimulation does not alter the protein composition of membrane domains in spite of dramatic changes induced in a specific signaling cascade.
- Effect of lipopolysaccharide and chlorpromazine on glucocorticoid receptor-mediated gene transcription and immunoreactivity: a possible involvement of p38-MAP kinase
- The effect of cocaine sensitization on mouse immunoreactivity
- Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding
- Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL
- Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases
- Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis
- Distinct localization of a beta-tubulin epitope in the Tetrahymena thermophila and Paramecium caudatum cortex
- Agonist-induced tyrosine phosphorylation of Gq/G11 alpha requires the intact structure of membrane domains
- Characterization of [3H]-forskolin binding sites in young and adult rat brain cortex: identification of suramin as a competitive inhibitor of [3H]-forskolin binding.
- New monoclonal antibodies to rat testicular antigen, TEC-21.
- The N-terminal region and the mid-region complex of the integrin beta 2 subunit.
- Alloantigen-induced, T-cell-dependent production of nitric oxide by macrophages infiltrating skin allografts in mice
- Adapters in lymphocyte signaling.
- Apoptosis of TF-1 cells induced by engagement of CD43: roles of transcription, expression of Daxx and adhesion molecules.
- Alloantigen-induced, T-cell-dependent production of nitic oxide by macrophagesinfiltrating skin allografts in mice.
- A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fce receptor.
- Different degree of cooperativity in adult, embryonic and mutated mouse muscle nicotinic receptors
- Differantial role of glycolipid-enriched mambrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets.
- Disulfide bond-mediated dimerization of HLA-G on the cell surface.
- Hormone-induced subcellular redistribution of trimeric G protein
- Gamma-Tubulin In chicken Erythrocytes: Changes in Locakalization During Cell Differentiation of Cytoplasmic Complexes.
- Membrane rafts in immunoreceptor signaling: new doubts, new proofs?
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