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Description
  • Vnitřní aktivita látek stimulovat produkci oxidu dusnatého v kulturách peritoneálních makrofágů a myší je indikátorem jejich schopnosti aktivovat sekreci cytokinů a chemokinů u mononukleárních buněk lidské krve. Test na produkci dusnatého může být považován za ekonomický a poměrně spolehlivý přístup pro screeningové hodnocení imunostimulační aktivity látek u lidských buněk. (cs)
  • Intrinsic abilty of drugs and compounds to up-regulate in vitro production of nitric oxide in mouse and rat peritoneal macrophages is significantly correlated with their potential to activate secretion of cytokines and chemokines in human peripheral blood mononuclear cells. NO assay may be regarded as an efficient, economical and relatively reliable tool in primary screening for intrinsic immunostimulatory activity of compounds in human cell system.
  • Intrinsic abilty of drugs and compounds to up-regulate in vitro production of nitric oxide in mouse and rat peritoneal macrophages is significantly correlated with their potential to activate secretion of cytokines and chemokines in human peripheral blood mononuclear cells. NO assay may be regarded as an efficient, economical and relatively reliable tool in primary screening for intrinsic immunostimulatory activity of compounds in human cell system. (en)
Title
  • Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells
  • Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells (en)
  • Produkce oxidu dusnatého myšími a potkaními makrofágy: rychlý a účinný test pro screening imunostimulačních účinků léčiv u lidských buněk (cs)
skos:prefLabel
  • Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells
  • Nitric oxide production in mouse and rat macrophages: a rapid and efficient assay for screening of drugs immunostimulatory effects in human cells (en)
  • Produkce oxidu dusnatého myšími a potkaními makrofágy: rychlý a účinný test pro screening imunostimulačních účinků léčiv u lidských buněk (cs)
skos:notation
  • RIV/68378041:_____/07:00091218!RIV08-AV0-68378041
http://linked.open.../vavai/riv/strany
  • 160;169
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1M0508), P(GA305/07/0061), Z(AV0Z40550506), Z(AV0Z50390512)
http://linked.open...iv/cisloPeriodika
  • -
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 437358
http://linked.open...ai/riv/idVysledku
  • RIV/68378041:_____/07:00091218
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Cytokines; Nitric oxide; Immunobiological screening (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [41AA3FB079A2]
http://linked.open...i/riv/nazevZdroje
  • Nitric Oxide-Biology and Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 17
http://linked.open...iv/tvurceVysledku
  • Holý, Antonín
  • Zídek, Zdeněk
  • Farghali, H.
  • Kmoníčková, Eva
  • Melkusová, Petra
http://linked.open...n/vavai/riv/zamer
issn
  • 1089-8603
number of pages
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