About: Irradiated stem cells and ageing of the haematopoietic system

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. (en)
Title	Irradiated stem cells and ageing of the haematopoietic system Irradiated stem cells and ageing of the haematopoietic system (en)
skos:prefLabel	Irradiated stem cells and ageing of the haematopoietic system Irradiated stem cells and ageing of the haematopoietic system (en)
skos:notation	RIV/68081707:_____/12:00390349!RIV13-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(OVUOFVZ200806), Z(AV0Z50040702), Z(MO0FVZ0000501)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	143048
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/12:00390349
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Irradiation; Ageing of haematopoiesis; Anaemia (en)
http://linked.open.../riv/klicoveSlovo	Irradiation Ageing of haematopoiesis Anaemia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[88BCCD839067]
http://linked.open...i/riv/nazevZdroje	Radiation and Environmental Biophysics
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Lukášová, Emilie Řezáčová, M. Vávrová, J. Filip, S. Mokrý, J. Šinkorová, Z. Tichý, A.
http://linked.open...ain/vavai/riv/wos	000303464400010
http://linked.open...n/vavai/riv/zamer	Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions Zdravotnická problematika ZHN
issn	0301-634X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00411-012-0401-5
is http://linked.open...avai/riv/vysledek of	Irradiated stem cells and ageing of the haematopoietic system

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