About: Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins. The new antitumor monofunctional Ru(II)-arene complex [eta6-arene)Ru(II)(en)Cl]+, where en = [1,2-diaminoethane and the arene is para-terphenyl] inhibits growth of the cancer cells through induction of apoptotic cell death and G0/G1 cell cycle arrest. Further investigations have shown that the ruthenium complex induces apoptosis by regulating the expression of Bc1-2 family proteins. (en)
Title	Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand (en)
skos:prefLabel	Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand (en)
skos:notation	RIV/68081707:_____/11:00365895!RIV12-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD301/09/H004), P(LC06030), P(OC09018), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kašpárková, Jana Kisová-Halámiková, Anna Zerzánková, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	194565
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00365895
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ruthenium; antitumor; cellular response (en)
http://linked.open.../riv/klicoveSlovo	antitumor cellular response ruthenium
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[4A9253D645A5]
http://linked.open...i/riv/nazevZdroje	MOLECULAR PHARMACEUTICS
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Biomolecular centre Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	8
http://linked.open...iv/tvurceVysledku	Brabec, V. Habtemariam, A. Kašpárková, Jana Kisová-Halámiková, Anna Sadler, P. J. Zerzánková, Lenka
http://linked.open...ain/vavai/riv/wos	000291233800032
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1543-8384
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/mp200105d
is http://linked.open...avai/riv/vysledek of	Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand Differences in the cellular response and signaling pathways between cisplatin and monodentate organometallic Ru(II) antitumor complexes containing a terphenyl ligand

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