About: Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn. Guanine-rich DNA sequences tend to form four-stranded G-quadruplex structures. Characteristic glycosidic conformational patterns along the G-strands, such as the 50-syn-anti-syn-anti pattern observed with the Oxytricha nova telomeric G-quadruplexes, have been well documented. However, an explanation for these featured glycosidic patterns has not emerged. This work presents MD simulation and free energetic analyses for simplified two-quartet [d(GG)]4 models and suggests that the four base pair step patterns show quite different relative stabilities: syn-anti>anti-anti>anti-syn->syn-syn. (en)
Title	Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes (en)
skos:prefLabel	Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes (en)
skos:notation	RIV/68081707:_____/11:00365887!RIV12-AV0-68081707
http://linked.open...avai/predkladatel	Biofyzikální ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/09/1476), P(IAA400040802), P(LC06030), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Šponer, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	198956
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/11:00365887
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	quantum chemistry; DNA; quadruplex (en)
http://linked.open.../riv/klicoveSlovo	quadruplex quantum chemistry DNA
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E9C3049DC9A0]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomolecular centre Structural dynamics, molecular interactions and function of key RNA motifs Structure, dynamics, and reaction mechanism of catalytic RNA
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Šponer, Jiří Cang, X. Cheatham III, T. E.
http://linked.open...ain/vavai/riv/wos	000291063500048
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0305-1048
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/nar/gkr031
is http://linked.open...avai/riv/vysledek of	Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes Explaining the varied glycosidic conformational, G-tract length and sequence preferences for anti-parallel G-quadruplexes

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software