About: Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages

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About: Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Stimulace produkce NO makrofágy aktivovanými endotoxinem vyžaduje tvorbu RKDM závislou na NADPH oxidázách a iNOS. Inhibice produkce NO makrofágy pomocí DPI není způsobeno pouze inhibicí aktivity iNOS, ale snížením exprese tohoto enzymu, což potvrzuje roli RKDM v aktivaci makrofágů endotoxinem. Lze tedy konstatovat, že modulace intracelulární tvorby RKDM může mít farmakologické uplatnění při léčbě plicního zánětu spojeného s expozicí endotoxinem. (cs) Intracellular reactive oxygen and nitrogen species (RONS) produced by NADPH oxidases and NOS are suggested to be important mediators augmenting the response of cells to endotoxin. Through this mechanisms NO could positively promote NOS expression and further increase of NO production. The aim of this study was to characterize modulation of endotoxin activated macrophage NO production by the inhibition of RONS producing NADPH oxidases and NOS. Intracellular reactive oxygen and nitrogen species (RONS) produced by NADPH oxidases and NOS are suggested to be important mediators augmenting the response of cells to endotoxin. Through this mechanisms NO could positively promote NOS expression and further increase of NO production. The aim of this study was to characterize modulation of endotoxin activated macrophage NO production by the inhibition of RONS producing NADPH oxidases and NOS. (en)
Title	Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages (en) Inhibitory NADPH oxidázy snižují endotoxinem zprostředkovanou indukci exprese inducibilní syntázy oxidu dusnatého u myších makrofágů (cs)
skos:prefLabel	Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages (en) Inhibitory NADPH oxidázy snižují endotoxinem zprostředkovanou indukci exprese inducibilní syntázy oxidu dusnatého u myších makrofágů (cs)
skos:notation	RIV/68081707:_____/07:00099404!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	s203;s204
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/06/1197), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	14
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Lojek, Antonín Okénková, Kateřina Konopka, Roman Kubala, Lukáš Viačková, Daniela
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	426670
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00099404
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipopolysaccharide; inhibitors of NADPH oxidase; macrophages (en)
http://linked.open.../riv/klicoveSlovo	lipopolysaccharide macrophages inhibitors of NADPH oxidase
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[33B09F2AD4D1]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Role of free radicals in the regulation of lung inflammation induced by acute and chronic exposure to endotoxin
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	101
http://linked.open...iv/tvurceVysledku	Kubala, Lukáš Lojek, Antonín Krejčová, Daniela Konopka, Roman Okénková, Kateřina
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	1213-7103
number of pages	2 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages Inhibitors of NADPH oxidase decrease endotoxin mediated induction of inducible nitric oxide expression in mouse macrophages

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