About: The role of actin and microtubule networks in plasmid DNA intracellular trafficking

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tato práce je zaměřena na poznání funkce acetinového a mikrotubulárního cytoskeletu v transportu plasmidové DNA během lipozomální transfekce. Pozorovali jsme silnou vazbu komplexů plasmidové DNA a lipidů k oběma cytoskeletárním sítím. Narušení těchto sítí vedlo k zastavení transpjortu plasmidů do buněčného jádra a k akumulaci plasmidové DNA do velkých agregátů lokalizovaných na periferii buněk. (cs) This work is focused on the function of the microtubule and actin networks in plasmid DNA transport during liposomal transfection. We observed strong binding of plasmid DNA-lipid complexes to both networks. Disruption of either of these networks led to the cessation of plasmid transport to the nucleus and accumulation of plasmid DNA in large aggregates at the cell periphery. This work is focused on the function of the microtubule and actin networks in plasmid DNA transport during liposomal transfection. We observed strong binding of plasmid DNA-lipid complexes to both networks. Disruption of either of these networks led to the cessation of plasmid transport to the nucleus and accumulation of plasmid DNA in large aggregates at the cell periphery. (en)
Title	The role of actin and microtubule networks in plasmid DNA intracellular trafficking Úloha aktinových a mikrotubulárních sítí ve vnitrobuněčném transportu plasmidové DNA (cs) The role of actin and microtubule networks in plasmid DNA intracellular trafficking (en)
skos:prefLabel	The role of actin and microtubule networks in plasmid DNA intracellular trafficking Úloha aktinových a mikrotubulárních sítí ve vnitrobuněčném transportu plasmidové DNA (cs) The role of actin and microtubule networks in plasmid DNA intracellular trafficking (en)
skos:notation	RIV/68081707:_____/07:00087650!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany	657;663
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1QS500040508), P(GA202/02/0804), P(GA202/04/0907), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Ondřej, Vladan Kozubek, Stanislav Falk, Martin Lukášová, Emilie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	448164
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00087650
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	plasmid DNA; actin filaments; microtubules (en)
http://linked.open.../riv/klicoveSlovo	plasmid DNA microtubules actin filaments
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[D0AF8729B36C]
http://linked.open...i/riv/nazevZdroje	Acta Biochimica Polonica
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission Chromosome dynamics and organization during the cell cycle in normal and pathologic conditions Chronic myeloid leukemia radiation risk estimation based on BCR-ABL distances in hemotopoietic cells High-resolution cytomery of living cells
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Kozubek, Stanislav Lukášová, Emilie Ondřej, Vladan Falk, Martin
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems Genome and epigenome: 1D and 3D Structure, Dynamics, Interactions with Proteins and Functions
issn	0001-527X
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	The role of actin and microtubule networks in plasmid DNA intracellular trafficking The role of actin and microtubule networks in plasmid DNA intracellular trafficking The role of actin and microtubule networks in plasmid DNA intracellular trafficking

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