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Description
  • Tato práce je zaměřena na poznání funkce acetinového a mikrotubulárního cytoskeletu v transportu plasmidové DNA během lipozomální transfekce. Pozorovali jsme silnou vazbu komplexů plasmidové DNA a lipidů k oběma cytoskeletárním sítím. Narušení těchto sítí vedlo k zastavení transpjortu plasmidů do buněčného jádra a k akumulaci plasmidové DNA do velkých agregátů lokalizovaných na periferii buněk. (cs)
  • This work is focused on the function of the microtubule and actin networks in plasmid DNA transport during liposomal transfection. We observed strong binding of plasmid DNA-lipid complexes to both networks. Disruption of either of these networks led to the cessation of plasmid transport to the nucleus and accumulation of plasmid DNA in large aggregates at the cell periphery.
  • This work is focused on the function of the microtubule and actin networks in plasmid DNA transport during liposomal transfection. We observed strong binding of plasmid DNA-lipid complexes to both networks. Disruption of either of these networks led to the cessation of plasmid transport to the nucleus and accumulation of plasmid DNA in large aggregates at the cell periphery. (en)
Title
  • The role of actin and microtubule networks in plasmid DNA intracellular trafficking
  • Úloha aktinových a mikrotubulárních sítí ve vnitrobuněčném transportu plasmidové DNA (cs)
  • The role of actin and microtubule networks in plasmid DNA intracellular trafficking (en)
skos:prefLabel
  • The role of actin and microtubule networks in plasmid DNA intracellular trafficking
  • Úloha aktinových a mikrotubulárních sítí ve vnitrobuněčném transportu plasmidové DNA (cs)
  • The role of actin and microtubule networks in plasmid DNA intracellular trafficking (en)
skos:notation
  • RIV/68081707:_____/07:00087650!RIV08-AV0-68081707
http://linked.open.../vavai/riv/strany
  • 657;663
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(1QS500040508), P(GA202/02/0804), P(GA202/04/0907), P(LC535), Z(AV0Z50040507), Z(AV0Z50040702)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 448164
http://linked.open...ai/riv/idVysledku
  • RIV/68081707:_____/07:00087650
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • plasmid DNA; actin filaments; microtubules (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • PL - Polská republika
http://linked.open...ontrolniKodProRIV
  • [D0AF8729B36C]
http://linked.open...i/riv/nazevZdroje
  • Acta Biochimica Polonica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 54
http://linked.open...iv/tvurceVysledku
  • Kozubek, Stanislav
  • Lukášová, Emilie
  • Ondřej, Vladan
  • Falk, Martin
http://linked.open...n/vavai/riv/zamer
issn
  • 0001-527X
number of pages
is http://linked.open...avai/riv/vysledek of
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