About: Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this paper we have investigated hypomethylation capacities of alpha and beta anomers of 5-aza-2'-deoxycytidine. Surprisingly, alpha anomer induced DNA hypomethylation of the extent comparable with that of beta anomer. However, alpha anomer appeared to be approx. 5 x less toxic than the beta anomer in leukemic cells in vitro. Thus alpha anomer seems to be a promising agent for epigenetic therapy. In this paper we have investigated hypomethylation capacities of alpha and beta anomers of 5-aza-2'-deoxycytidine. Surprisingly, alpha anomer induced DNA hypomethylation of the extent comparable with that of beta anomer. However, alpha anomer appeared to be approx. 5 x less toxic than the beta anomer in leukemic cells in vitro. Thus alpha anomer seems to be a promising agent for epigenetic therapy. (en) V této práci jsme zkoumali hypometylační schopnosti alfa a beta anomeru 5-aza-2'-deoxycytidine. Překvapivě alfa anomer indukoval hypometylaci DNA v rozsahu srovnatelném s beta anomerem. Při aplikaci na leukemické buňky in vitro byl alfa anomer 5 x méně toxický nežli beta anomer. Alfa anomer by se tak mohl stát slibnou látkou pro epigenetickou terapii. (cs)
Title	Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer (en) Stanovení hypometylačních účinků alfa a beta anomeru 5-aza-2'-deoxycytidinu (cs)
skos:prefLabel	Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer (en) Stanovení hypometylačních účinků alfa a beta anomeru 5-aza-2'-deoxycytidinu (cs)
skos:notation	RIV/68081707:_____/07:00080772!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	16;22
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA521/04/0775), P(IAA600040611), Z(AV0Z40550506), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kovařík, Aleš Bártová, Eva Fojtová, Miloslava
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	419327
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/07:00080772
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA methylation; 5-aza-2'-deoxycytidine; anomers (en)
http://linked.open.../riv/klicoveSlovo	5-aza-2'-deoxycytidine anomers DNA methylation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C2C40F14C7EF]
http://linked.open...i/riv/nazevZdroje	Pharmacological Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Epigenetic regulation of gene expression in transgenic and endogenous loci of higher plants Mendelian and non-mendelian interactions of the plant transgenes
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Bártová, Eva Kovařík, Aleš Votruba, Ivan Fojtová, Miloslava Otmar, Miroslav Pískala, Alois
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Biophysics of dynamic structures and functions of biological systems
issn	1043-6618
number of pages	7 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer Efficacy of DNA hypomethylating capacities of 5-aza-2'-deoxycytidine and its alpha anomer

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