About: Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations

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About: Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Na základě CD spektroskopie ukazujeme, že etanol indukuje guaninové tetraplexy stejně nebo dokonce lépe než draselné kationty. Uvádíme příklady guaninových tetraplexů stabilizovaných etanolem v případech, kdy draselné kationty tetraplex nestabilizují. Etanol tedy mimo formu A- a Z-DNA stabilizuje další uspořádání - guaninové tetraplexy. Diskutujeme mechanismus jejich stabilizace. Tato práce ukazuje, že spektrum nukleotidových sekvencí, které mohou tvořit guaninové tetraplexy, je širší než se původně předpokládalo. Navíc vodný roztok etanolu pravděpodobně simuluje lépe podmínky in vivo než vodné roztoky. (cs) Here we show using CD spectroscopy that ethanol induces the guanine tetraplexes like or even better than potassium cations. We present examples of ethanol stabilizing guanine tetraplexes even in cases when potassium cations fail to do so. Hence, besides the A-form or Z-form, ethanol stabilizes another conformation of DNA, i.e., the guanine tetraplexes. We discuss mechanism of the stabilization. Use of ethanol will permit studies of guanine tetraplexes that cannot be induced by potassium cations or other tetraplex-promoting agents. This work demonstrates that a still broader spectrum of nucleotide sequences can fold into guanine tetraplexes than has previously been thought. Aqueous ethanol may better simulate conditions existing in vivo than the aqueous solutions. Here we show using CD spectroscopy that ethanol induces the guanine tetraplexes like or even better than potassium cations. We present examples of ethanol stabilizing guanine tetraplexes even in cases when potassium cations fail to do so. Hence, besides the A-form or Z-form, ethanol stabilizes another conformation of DNA, i.e., the guanine tetraplexes. We discuss mechanism of the stabilization. Use of ethanol will permit studies of guanine tetraplexes that cannot be induced by potassium cations or other tetraplex-promoting agents. This work demonstrates that a still broader spectrum of nucleotide sequences can fold into guanine tetraplexes than has previously been thought. Aqueous ethanol may better simulate conditions existing in vivo than the aqueous solutions. (en)
Title	Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations (en) Etanol indukuje guaninové DNA tetraplexy lépe než draselné kationty (cs)
skos:prefLabel	Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations (en) Etanol indukuje guaninové DNA tetraplexy lépe než draselné kationty (cs)
skos:notation	RIV/68081707:_____/06:00039039!RIV07-AV0-68081707
http://linked.open.../vavai/riv/strany	253;260
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA4004201), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kypr, Jaroslav Vorlíčková, Michaela Bednářová, Klára
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	474499
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/06:00039039
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	DNA; guanine tetraplexes; ethanol (en)
http://linked.open.../riv/klicoveSlovo	DNA ethanol guanine tetraplexes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D525FC84DBF4]
http://linked.open...i/riv/nazevZdroje	Biopolymers
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Tetraplexes of DNA and Their Occurrence in the Human Genome
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	82
http://linked.open...iv/tvurceVysledku	Kypr, Jaroslav Vorlíčková, Michaela Bednářová, Klára
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0006-3525
number of pages	8 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations Ethanol is a better inducer of DNA guanine tetraplexes than potassium cations

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