About: DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes

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About: DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interactions of DNA with antitumor trans-[PtCl2(E-iminoether)2] were investigated using the methods of molecular biophysics. It has been found that unexpected antitumor effects of this complex are associated with its capability to form DNA-protein cross-links. Interactions of DNA with antitumor trans-[PtCl2(E-iminoether)2] were investigated using the methods of molecular biophysics. It has been found that unexpected antitumor effects of this complex are associated with its capability to form DNA-protein cross-links. (en) Byly studovány interakce DNA s novým protinádorově účinným komplexem trans-[PtCl2(E-iminoether)2] metodami molekulární biofyziky. Bylo zjištěno, že za neočekávané protinádorové účinky tohoto komplexu jsou zodpovědné můstky, které tato platinová sloučenina vytváří mezi DNA a proteiny. (cs)
Title	DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes (en) Tvorba mustků mezi DNA a proteiny komplexem trans-[PtCl2(E-iminoether)] (cs)
skos:prefLabel	DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes DNA-protein cross-linking by trans-[PtCl2(E-iminoetherú2]. A concept for activation of the trans geometry in platinum antitumor complexes (en) Tvorba mustků mezi DNA a proteiny komplexem trans-[PtCl2(E-iminoether)] (cs)
skos:notation	RIV/68081707:_____/03:00032356!RIV06-AV0-68081707
http://linked.open.../vavai/riv/strany	6450;6460
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/02/1552), P(KJB5004301), P(OC D20.004), P(OC D21.001), Z(AV0Z50040507)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Nováková, Olga Malina, Jaroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biofyzikální ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	604251
http://linked.open...ai/riv/idVysledku	RIV/68081707:_____/03:00032356
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	antitumor drug; DNA; protein (en)
http://linked.open.../riv/klicoveSlovo	DNA protein antitumor drug
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BC9BE682BD87]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20D20.004 http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20D21.001 Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. Molecular mechanisms underlying anticancer effects of a new drug BBR3464
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	31
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Malina, Jaroslav Nováková, Olga Natile, G.
http://linked.open...n/vavai/riv/zamer	Biophysics of dynamic structures and functions of biological systems
issn	0305-1048
number of pages	11 (xsd:int)

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