About: Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

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About: Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS The additive effect of endothelin-1 blockade to renin-angiotensin blockade was evaluated in rats with ablation nephrectomy. While RAS blockade normalized blood pressure (BP), improved survival, decreased cardiac hypertrophy and proteinuria as well as tissue angiotensin II and ET-1 levels, ETA receptor blockade only partially improved survival rate, reduced BP, attenuated the development of cardiac hypertrophy and transiently reduced proteinuria. No additive cardio- and renoprotective effects of ETA and RAS blockade were noted at the end of the study suggesting that the RAS system is the main target for antihypertensive treatment in models with inappropriately activated RAS (en)
Title	Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats (en)
skos:prefLabel	Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats (en)
skos:notation	RIV/67985823:_____/12:00390670!RIV13-AV0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(LH11116), P(NS10499), P(NS10500), P(NS9703), P(NT12171), S, Z(AV0Z50110509)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Vaněčková, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	133429
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/12:00390670
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	5/6 nephrectomy; Endothelin receptor type A; AT1 receptor blocker; end-organ damage; hypertension (en)
http://linked.open.../riv/klicoveSlovo	hypertension - ischaemic heart disease - cardiac failure - vitamin D 5/6 nephrectomy AT1 receptor blocker Endothelin receptor type A end-organ damage
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[48710F96BC1E]
http://linked.open...i/riv/nazevZdroje	Kidney & Blood Pressure Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Novel approach to blood pressure control and organ protection- intervention to renin-angiotensin and endothelin systems The mechanisms of interaction between renin-angiotensin-aldosterone system, cytochrome P450 metabolites and other vasoactive systems in the regulation of blood pressure and the impact on pathophysiology of salt-sensitive hypertension and renal injury The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis. The role of impairment of pressure-natriuresis mechanism in the pathophysiology of angiotensin II-dependent malignant form of hypertension The interaction between renin-angiotensin and endothelin systems in the pathogenesis of renal failure and cardiac hypertrophy in hypertensive rats
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Vaněčková, Ivana Červenka, L. Škaroupková, P. Vernerová, Z. Kramer, H. J. Tesař, V. Husková, Z. Kujal, P. Vaňourková, Z. Čertíková - Chábová, V.
http://linked.open...ain/vavai/riv/wos	000305594600011
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka
issn	1420-4096
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000336823
is http://linked.open...avai/riv/vysledek of	Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats

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