About: The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis.

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About: The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=NT12171
Description	The role of arachidonic acid metabolites in the pathophysiology of hypertensive organ damage will be studied via targeted inhibition of the enzyme catalyzing conversion of vasodilatory epoxyeicosatrienoic acids and via inhibition of vasoconstrictive 20-hydroxyeicosatetraenoic acids production. (en) Objasnění úlohy metabolitů kyseliny arachidonové v patofyziologii hypertenzního orgánového poškození pomocí cílené inhibice enzymu katalyzujícího přeměnu vazodilatačních epoxyeikosatrienových kyselin (EETs) a pomocí inhibice tvorby vazokonstrikčních 20-hydroxyeikosatetraenových kyselin (20-HETE).
Title	The role of abnormalities in the metabolic pathway of cytochrome P450 in the pathophysiology of hypertensive organ damage: posibilities of prevention and ragression of glomerulosclerosis. (en) Úloha abnormalit v metabolické cestě cytochromu P450 v patofyziologii hypertenzního orgánového poškození: možnosti prevence a regrese glomerulosklerózy.
skos:notation	NT12171
http://linked.open...avai/cep/aktivita	Ministry of Health’s Departmental Research and Development Programme III
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http://linked.open...datumDodatniDoRIV	2015-01-22 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	100901258
http://linked.open...ai/cep/hlavniObor	FE - Ostatní obory vnitřního lékařství
http://linked.open...vai/cep/kategorie	NV - Aplikovaný výzkum s výjimkou průmyslového výzkumu (tzv. %22neprůmyslový výzkum%22)
http://linked.open.../cep/klicovaSlova	hypertension; renal failure; cytochrome P450 metabolites; renin-angiotensin system; hypertension treatment (en)
http://linked.open...ep/partnetrHlavni	Institut klinické a experimentální mediciny
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
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http://linked.open...lneniVMinulemRoce	2014-03-21 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/NT12171-5%2F2011
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	SMZ0201101
http://linked.open...usZobrazovaneFaze	DRRVK
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2015-12-31 (xsd:date)
http://linked.open...ep/zahajeniReseni	2011-06-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBBK
http://linked.open.../cep/klicoveSlovo	hypertension cytochrome P450 metabolites renal failure renin-angiotensin system
is http://linked.open...vavai/riv/projekt of	Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME Antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats is mediated by suppression of the intrarenal reninangiotensin system Effects of Combined Endothelin A Receptor and Renin-Angiotensin System Blockade on the Course of End-Organ Damage in 5/6 Nephrectomized Ren-2 Hypertensive Rats Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NT12171/2011/ico%3A00023001 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NT12171/2012/ico%3A00023001 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NT12171/2013/ico%3A00023001 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NT12171/2014/ico%3A00023001 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/NT12171/2015/ico%3A00023001

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