About: Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis

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About: Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue We investigated potential autocrine effects of resistin on lipid and glucose metabolism in 2- and 16-mo-old transgenic spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin under control of the aP2 promoter. Our results suggest that with increasing age autocrine effects of resistin in fat tissue may predispose to diabetes in part by impairing insulin action in adipose tissue (en)
Title	Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis (en)
skos:prefLabel	Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis (en)
skos:notation	RIV/67985823:_____/11:00359445!RIV12-MZ0-67985823
http://linked.open...avai/predkladatel	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(IAA500110805), P(ME08006), P(NS9757), P(NS9759), S, Z(AV0Z50110509), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zídek, Václav Mlejnek, Petr Šimáková, Miroslava Landa, Vladimír Pravenec, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	184861
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/11:00359445
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transgenic rat; adipose tissue; insulin resistance; autocrine effects (en)
http://linked.open.../riv/klicoveSlovo	adipose tissue autocrine effects insulin resistance transgenic rat
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[80BE2CAC4DE1]
http://linked.open...i/riv/nazevZdroje	Physiological Genomics
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research Analysis of mechanisms of adipokine autocrine effects on glucose and lipid metabolism Genetic and correlation analyses of ectopic fat accumulation and adipose tissue oxidative/inflammatory processes and their role in the pathogenesis of insulin resistance The role of C reactive protein in the pathogenesis of metabolic syndrome: nutritional and pharmacological interventions Genetic causes of mitochondrial diseases due to deficiency of ATP synthase
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Eminaga, S. Gorham, J. Kazdová, L. Kurtz, T. W. Landa, Vladimír Maxová, M. Mlejnek, Petr Pravenec, Michal Seidman, Ch. E. Seidman, J. G. Wang, J. Zídek, Václav Šilhavý, J. Šimáková, Miroslava
http://linked.open...ain/vavai/riv/wos	000289408400006
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	1094-8341
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1152/physiolgenomics.00112.2010
is http://linked.open...avai/riv/vysledek of	Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis

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