About: Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat

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About: Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We found that the gene for ADD1/SREBP-1c maps to a region of rat Chromosome 10 previously reported to contain a quantitative trait locus involved in the regulation of hepatic cholesterol levels and the SHR harbors a unique mutation. The SREBP-1 isoforms might contribute to inherited variation in lipid metabolism in the SHR versus other strains of rats We found that the gene for ADD1/SREBP-1c maps to a region of rat Chromosome 10 previously reported to contain a quantitative trait locus involved in the regulation of hepatic cholesterol levels and the SHR harbors a unique mutation. The SREBP-1 isoforms might contribute to inherited variation in lipid metabolism in the SHR versus other strains of rats (en) Bylo zjištěno, že ADD1/SREBP-1 mapuje do oblasti chromozomu 10, kde se nachází QTL asociovaný s jaterním cholesterolem a že kmen SHR nese unikátní mutaci. SREBP-1 izoformy by mohly být asociovany s variabilitou lipidového metabolizmu při srovnání kmene SHR s jinými kmeny (cs)
Title	Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat (en) Identifikace mutace v ADD1/SREBP-1 u spontánně hypertenzních potkanů (cs)
skos:prefLabel	Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat (en) Identifikace mutace v ADD1/SREBP-1 u spontánně hypertenzních potkanů (cs)
skos:notation	RIV/67985823:_____/01:00142131!RIV07-AV0-67985823
http://linked.open.../vavai/riv/strany	295;298
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA305/00/1646), P(GV204/98/K015), P(LN00A079), Z(AV0Z5011922), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kostka, Vlastimil Zídek, Václav Pravenec, Michal Křen, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fyziologický ústav AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	682257
http://linked.open...ai/riv/idVysledku	RIV/67985823:_____/01:00142131
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mutations in genes; ADD1/SREBP-1c; spontaneously hypertensive rat (en)
http://linked.open.../riv/klicoveSlovo	spontaneously hypertensive rat ADD1/SREBP-1c mutations in genes
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[945A503D10E4]
http://linked.open...i/riv/nazevZdroje	Mammalian Genome
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular mapping and positional cloning of genes that are responsible for clustering of cardiovascular risk factors Center of Integrated Genomics Molecular mapping of the mammalian genome and positional cloning of mammalian genes
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Forejt, Jiří Jansa, Petr Křen, Vladimír Pravenec, Michal Zídek, Václav Kurtz, W. T. Kostka, Vlastimil
http://linked.open...n/vavai/riv/zamer	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0938-8990
number of pages	4 (xsd:int)

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