About: Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease

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About: Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Zamer, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Zamer
Description	Cílem je získávat nové poznatky o funkcích subcelulárních složek, buněk, orgánů i celého organismu a o vývoji těchto funkcí k prohloubení teoretických základů humánní mediciny. Práce se zaměří na strukturu, látkovou přeměnu a energetiku buněk, transportní funkci membrán, přenos signálů unitř buněk i mezi buňkami a na genetické podklady těchto funkcí, dále na funkci srdečního svalu a její vývojové aspekty, experimentální hypertenzi, atherosklerózu a na integrativní funkce nervového systému. Prudký vývoj molekulární biologie a genetiky nám dovolí získání nových údajů pomocí použití metod molekulární biologie v tradičních oblastech systémové fyziologie (kardiovaskulární a centrální nervový systém) v návaznosti na základní orientaci na přenos signálů, membránový transport a energetický metabolismus. Výsledky přispějí k objasnění patogenetických mechanismů chorob kardiovaskulárního a nervového systému a metabolismu a jejich racionální diagnostice a terapii. The Institute aims to increase the understanding of physiology including the developmental aspects by studies of subcellular components, cells, organs and whole animals as a theoretical basis of human medicine. Work will focus on cell structure, metabolism and energetics, membrane transport, signal transmission, and their genetic determination as well as on cardiac function and its developmental aspects, experimental hypertension, atherosclerosis, and integrative functions of the nervous system. Progressive development of molecular biology and genetics will allow that new data will be obtained by means of application of methods of molecular biology in traditional fields of system physiology (cardiovascular and central nervous system) in close connection with the basic orientation on signal transmission, membrane transport and energy metabolism. Results will clarify pathogenetic mechanisms of cardiovascular, nervous and metabolic diseases and advance their diagnostics and therapy. (en)
Title	Investigation of normal and pathological physiology of animals - the clarification of the physiological mechanisms operating in humans in health and disease (en) Výzkum normální a patologické fyziologie živočichů - funkcí buněk a orgánů s cílem objasnit základní mechanismy činnosti lidského organismu v normě a patologii
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5011922/celkovaStatniPodpora
http://linked.open...ez/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/zamer/AV0Z5011922/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2005-06-17 (xsd:date)
http://linked.open...vavai/cez/dodavka	http://linked.opendata.cz/resource/domain/vavai/dodavka/CEZ%2F2005%2FAV0%2FAV0500%2FU%2FN%2F3%3A1
http://linked.open...ez/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...in/vavai/cez/faze	33123727
http://linked.open...ai/cez/hlavniObor	ED - Fyziologie
http://linked.open...vai/cez/hodnoceni	V - Vynikající výsledky (s mezinárodním významem apod.). Zároveň byly splněny cíle a předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory.
http://linked.open.../cez/kategorieVaV	ZV - Základní výzkum
http://linked.open.../cez/klicovaSlova	heart;vessel;nervous system;muscles;connective tissue;fat tissue;cell cultures;metabolism;energy;molecular biology;membranes;cell;receptors;signal transduction;mediators;biochemistry;transport mechanism;evolution;memory;pain;epilepsy;circadial rhythm (en)
http://linked.open...icUkonceniPodpory	1 (xsd:int)
http://linked.open...icZahajeniPodpory	1 (xsd:int)
http://linked.open...cez/partnerHlavni	Fyziologický ústav AV ČR, v.v.i.
http://linked.open...z/poceVysledkuRIV	845 (xsd:int)
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cez/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	0 (xsd:int)
http://linked.open...enychVysledkuVRIV	845 (xsd:int)
http://linked.open.../vavai/cez/resort	Academy of Sciences of the Czech Republic
http://linked.open...okUkonceniPodpory	2004
http://linked.open...okZahajeniPodpory	1999
http://linked.open...iciPoslednihoRoku	2005
http://linked.open...atUdajeProjZameru	2005
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open.../cez/vedlejsiObor	FA - Kardiovaskulární nemoci včetně kardiochirurgie FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...n/vavai/cez/zamer	Z - Výzkumný záměr financovaný ze státního rozpočtu
http://linked.open...sledkuDodavatelem	Výsledky významně rozšířily naše chápání fyziologických a patofyziologických procesů na úrovni molekulární, buněčné, orgánové a celého organismu se zřetelem k hlubšímu poznání patofyziologických procesů u člověka. (cs) The results significantly improved our understanding of physiological and pathological processes on molecular, cellular, organ and whole-body levels with special attention to increase the general knowledge of theoretical bases of human pathophysiology. (en)
http://linked.open...cez/zivotniCyklus	ZBBBBKU
is http://linked.open...n/vavai/riv/zamer of	Stereological and digital methods for estimating geometrical characteristics of biological structures using confocal microscopy Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutations Dědičné poruchy mitochondriální ATP syntázy Developmental changes of cytochrome c oxidase and citrate synthase in rat heart homogenate Deprese, trofika a kmenové buňky Confocal microscopy of the green-algal chloroplast Dependence of the biological half-lives of sodium and bromide on the animal's physiological state C-terminal Stretch Changes Its Conformation upon Ligand Binding and Phosphorylation at Thr Confocal stereology and image analysis: methods for estimating geometrical characteristics of cells and tissues from three-dimensional confocal images Corticosteroid regulation of colonic ion transport during postnatal development: methods for corticosteroid analysis Different types of noise in leaky integrate-and-fire model of neuronal dynamics with discrete periodical input Development of circadian rhythmicity and photoperiodic response in subdivisions of the rat suprachiasmatic nucleus Current and future possibilities of confocal and two-photon microscopy Cortical and limbic excitability in rats with absence epilepsy Genetic Defects of Cytochrome c Oxidase Assembly GUG is an efficient initiation codon to translate the human mitochondrial ATP6 gene Glycerophosphate-dependent hydrogen peroxide production by rat liver mitochondria Genetic absence rats have a lower threshold for limbic type of afterdischarges: a cortical stimulation study Hippocampal afterdischarges in rats. I. Effects of antiepilepticus Gender differences in plasma levels of lipoprotein (a) in patients with angiographically proven coronary artery disease Genetic analysis of %22metabolic syndrome%22 in the spontaneously hypertensive rat Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors The hydrogen bonds between Arg423 and Glu472 and other key residues, Asp443, Ser477, and Pro489, are responsible for the formation and a different positioning of TNP-ATP and ATP within the nucleotide-binding site of Na(+)/K(+)-ATPase From spreading depression to spatial cognition Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2 Genetically modified S. cerevisiae strain expressing plant vacuolar Na+/H+ antiporter Nhx1 Mitochondrial Membrane Potential and ATP Production in Primary Disorders of ATP Synthase Mitochondrial diseases and ATPase defects of nuclear origin Long-term behavioral and morphological consequences of nonconvulsive status epilepticus in rats. Long-term agonist stimulation of IP prostanoid receptor depletes the cognate G(s)alpha protein in membrane domains but does not change the receptor level Metabolism of bromide and its interference with the metabolism of iodine Metabolism of iodine in the rat is markedly affected by high bromide intake Metabolism of bromide is influenced by sodium intake Mean instantaneous firing frequency is always higher than the firing rate Mitochondrial diseases and ATPase defects of nuclear origin Mitochondrial uncoupling proteins - facts and fantasies Melatonin action in neonatal gonadotrophs Mapping of cellular compartments based on ultrastructural immunogold labeling LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats: radiotelemetry study Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat Blood Capillary Length Estimation from Three-Dimensional Microscopic Data by Image Analysis and Stereology Opposite effects of a GABAB antagonist in two models of epileptic seizures in developing rats Metabotropic glutamate receptor antagonists but not NMDA antagonists affect conditioned taste aversion acquisition in the parabrachial nucleus of rats Spatial decisions in rats based on the geometry of computer-generated patterns Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current Biphasic effect of chronic postnatal caffeine treatment on cortical epileptic afterdischarges during ontogeny in rats Spatial choices of rats based on abstract visual information: Pattern- or configuration-discrimination? Operant behavior of the rat can be controlled by the configuration of objects in an animated scene displayed on a computer screen Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors Cognitive disorganization in hippocampus: a physiological model of the disorganization in psychosis Classification of stationary neuronal activity according to its information rate Similarity of interspike interval distributions and information gain in a stationary neuronal firing The increase of choline acetyltransferase activity by docosahexaenoic acid in NG108-15 cells grown in serum-free medium is independent of its effect on cell growth Antibody formation against beta-tubulin class III in response to brain trauma Electrical hypersensitivity and tissues generating electric current – mental construction and biological reality Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison Heterogeneous expression of melatonin receptor MT1 mRNA in the rat intestine under control and fasting conditions The effect of N-acetylcysteine and melatonin in adult spontaneously hypertensive rats with established hypertension Optimum signal in a diffusion leaky integrate-and-fire neuronal model Variability and randomness in stationary neuronal aktivity 11beta-hydroxysteroid dehydrogenase 1 and 2 expression in colon from patients with ulcerative colitis Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci Knihovna pro práci s BVD soubory Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes

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