About: Gene expression profiling in follicular lymphoma and its implication for clinical practice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Follicular lymphoma (FL) is characterized by an indolent and relapsing course. Recently, the clinical outcome of FL has been distinguished by immune microenvironment-associated gene signatures. In our study, gene expression profiling (GEP) was performed in 31 non-selected patients with follicular lymphoma (FL), 12 of whom were in relapse and the remaining 19 newly diagnosed. A custom oligonucleotide microarray was used which contained probes for about 3500 genes, including those that had been previously published as demonstrating significant prognostic value. An unsupervised approach was not able to recognize clinically different FLs. As the previously published prognostically relevant gene signatures could not be properly verified, probably due to microarray platform differences, template matching was therefore used in order to define two gene sets with differential gene expression among our samples. Follicular lymphoma (FL) is characterized by an indolent and relapsing course. Recently, the clinical outcome of FL has been distinguished by immune microenvironment-associated gene signatures. In our study, gene expression profiling (GEP) was performed in 31 non-selected patients with follicular lymphoma (FL), 12 of whom were in relapse and the remaining 19 newly diagnosed. A custom oligonucleotide microarray was used which contained probes for about 3500 genes, including those that had been previously published as demonstrating significant prognostic value. An unsupervised approach was not able to recognize clinically different FLs. As the previously published prognostically relevant gene signatures could not be properly verified, probably due to microarray platform differences, template matching was therefore used in order to define two gene sets with differential gene expression among our samples. (en)
Title	Gene expression profiling in follicular lymphoma and its implication for clinical practice Gene expression profiling in follicular lymphoma and its implication for clinical practice (en)
skos:prefLabel	Gene expression profiling in follicular lymphoma and its implication for clinical practice Gene expression profiling in follicular lymphoma and its implication for clinical practice (en)
skos:notation	RIV/65269705:_____/11:#0001275!RIV12-MZ0-65269705
http://linked.open...avai/predkladatel	Fakultní nemocnice Brno
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FR-TI2/254), P(NS10439), Z(MSM0021622430)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vášová, Ingrid Šálek, David Janíková, Andrea Pospíšilová, Šárka Mayer, Jiří Šupíková, Jana Křen, L. Tichý, Boris Stano Kozubík, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	200880
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/11:#0001275
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	follicular lymphoma (en)
http://linked.open.../riv/klicoveSlovo	follicular lymphoma
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[DB2B09287880]
http://linked.open...i/riv/nazevZdroje	Leukemia & Lymphoma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	*Real-time PCR kits for detection in oncology Analysis of changes in genome and its expression in chronic lymphocytic leukemia patients during the disease development
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Mayer, Jiří Pospíšilová, Šárka Janíková, Andrea Vášová, Ingrid Šálek, David Křen, Leoš Stano Kozubík, Kateřina Tichý, Boris Šupíková, Jana
http://linked.open...ain/vavai/riv/wos	000286901600012
http://linked.open...n/vavai/riv/zamer	Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
issn	1042-8194
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.3109/10428194.2010.531412
is http://linked.open...avai/riv/vysledek of	Gene expression profiling in follicular lymphoma and its implication for clinical practice Gene expression profiling in follicular lymphoma and its implication for clinical practice

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