About: Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We define two microscopy techniques enabling to distinguish and separate Dox and D* emission based either on its spectral properties or on fluorescence lifetime analysis. To analyze influx and nuclear accumulation of Dox (free or polymer-bound) by flow cytometry, we propose using an indirect method based on its DNA intercalation competition with Hoechst 33342 rather than a direct measurement od doxorubicin fluorescence inside the cells We define two microscopy techniques enabling to distinguish and separate Dox and D* emission based either on its spectral properties or on fluorescence lifetime analysis. To analyze influx and nuclear accumulation of Dox (free or polymer-bound) by flow cytometry, we propose using an indirect method based on its DNA intercalation competition with Hoechst 33342 rather than a direct measurement od doxorubicin fluorescence inside the cells (en)
Title	Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation (en)
skos:prefLabel	Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation (en)
skos:notation	RIV/61389013:_____/10:00352888!RIV11-MSM-61389013
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA400200702), P(IAAX00500803), P(LC06063), Z(AV0Z40400503), Z(AV0Z40500505), Z(AV0Z50200510)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Strohalm, Jiří Ulbrich, Karel Šubr, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	289131
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/10:00352888
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	doxorubicin; spectral analysis; fluorescence (en)
http://linked.open.../riv/klicoveSlovo	spectral analysis fluorescence doxorubicin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[E716B1B394A6]
http://linked.open...i/riv/nazevZdroje	European Journal of Pharmaceutics and Biopharmaceutics
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Flurescence microscopy in biological and medical research THE EFFECT OF HPMA DRUG BASED THERAPY ON THE LOCAL TUMOR MICROENVIRONMENT Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	76
http://linked.open...iv/tvurceVysledku	Hof, Martin Kovář, Lubomír Strohalm, Jiří Ulbrich, Karel Říhová, Blanka Větvička, David Šubr, Vladimír Benda, Aleš Strohalm, Martin Hovorka, Ondřej
http://linked.open...ain/vavai/riv/wos	000285279900027
http://linked.open...n/vavai/riv/zamer	Struktura, reaktivita a dynamika molekulárních a biomolekulárních systémů: teorie, experiment, aplikace Progresivní makromolekulární materiály a supramolekulární systémy: syntéza a studium vlastností, jevů a možností využití pro speciální aplikace a moderní technologie Microorganisms in Research and Biotechnology
issn	0939-6411
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

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